HTR2B (5-hydroxytryptamine receptor 2B)

2010-08-01  

Identity

HGNC
LOCATION
2q37.1
LOCUSID
ALIAS
5-HT(2B),5-HT-2B,5-HT2B
FUSION GENES

Other Information

Locus ID:

NCBI: 3357
MIM: 601122
HGNC: 5294
Ensembl: ENSG00000135914

Variants:

dbSNP: 3357
ClinVar: 3357
TCGA: ENSG00000135914
COSMIC: HTR2B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135914ENST00000258400P41595

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Gap junctionKEGGko04540
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Gap junctionKEGGhsa04540
Serotonergic synapseKEGGhsa04726
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
Serotonin receptorsREACTOMER-HSA-390666
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
235192152013Structural features for functional selectivity at serotonin receptors.200
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
281295382017Crystal Structure of an LSD-Bound Human Serotonin Receptor.72
211791622010A population-specific HTR2B stop codon predisposes to severe impulsivity.71
127670502003Functional activity of serotoninergic and melatoninergic systems expressed in the skin.61
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
233557312013Serotonin skews human macrophage polarization through HTR2B and HTR7.37
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
190231342009Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy.31

Citation

Dessen P

HTR2B (5-hydroxytryptamine receptor 2B)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51585/htr2b-(5-hydroxytryptamine-receptor-2b)