HTR2B (5-hydroxytryptamine receptor 2B)

2010-08-01  

Identity

HGNC
LOCATION
2q37.1
LOCUSID
ALIAS
5-HT(2B),5-HT-2B,5-HT2B
FUSION GENES

Other Information

Locus ID:

NCBI: 3357
MIM: 601122
HGNC: 5294
Ensembl: ENSG00000135914

Variants:

dbSNP: 3357
ClinVar: 3357
TCGA: ENSG00000135914
COSMIC: HTR2B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135914ENST00000258400P41595

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Gap junctionKEGGko04540
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Gap junctionKEGGhsa04540
Serotonergic synapseKEGGhsa04726
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
Serotonin receptorsREACTOMER-HSA-390666
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
385788942024The 5HT2b Receptor in Alzheimer's Disease: Increased Levels in Patient Brains and Antagonist Attenuation of Amyloid and Tau Induced Dysfunction.1
385788942024The 5HT2b Receptor in Alzheimer's Disease: Increased Levels in Patient Brains and Antagonist Attenuation of Amyloid and Tau Induced Dysfunction.1
360495412023miRNA-203b-3p Induces Acute and Chronic Pruritus through 5-HTR2B and TRPV4.4
367810422023Targeting serotonin receptor 2B inhibits TGFβ induced differentiation of human vascular smooth muscle cells.1
369580842023Pulmonary 5-HT(2B) receptor expression in fibrotic interstitial lung diseases.1
374800942023Variant rs17619600 in the gene encoding serotonin receptor 2B (HTR2B) increases the risk of gestational diabetes mellitus: a case-control study.0
377621362023Synergistic Interaction of 5-HT(1B) and 5-HT(2B) Receptors in Cytoplasmic Ca(2+) Regulation in Human Umbilical Vein Endothelial Cells: Possible Involvement in Pathologies.1
380374542023Neurotransmitter Receptor HTR2B Regulates Lipid Metabolism to Inhibit Ferroptosis in Gastric Cancer.5
360495412023miRNA-203b-3p Induces Acute and Chronic Pruritus through 5-HTR2B and TRPV4.4
367810422023Targeting serotonin receptor 2B inhibits TGFβ induced differentiation of human vascular smooth muscle cells.1
369580842023Pulmonary 5-HT(2B) receptor expression in fibrotic interstitial lung diseases.1
374800942023Variant rs17619600 in the gene encoding serotonin receptor 2B (HTR2B) increases the risk of gestational diabetes mellitus: a case-control study.0
377621362023Synergistic Interaction of 5-HT(1B) and 5-HT(2B) Receptors in Cytoplasmic Ca(2+) Regulation in Human Umbilical Vein Endothelial Cells: Possible Involvement in Pathologies.1
380374542023Neurotransmitter Receptor HTR2B Regulates Lipid Metabolism to Inhibit Ferroptosis in Gastric Cancer.5
351634912022Contribution of the STAT Family of Transcription Factors to the Expression of the Serotonin 2B (HTR2B) Receptor in Human Uveal Melanoma.6

Citation

Dessen P

HTR2B (5-hydroxytryptamine receptor 2B)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51585/htr2b-(5-hydroxytryptamine-receptor-2b)