Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3156
MIM: 142910
HGNC: 5006
Ensembl: ENSG00000113161
Variants:
dbSNP: 3156
ClinVar: 3156
TCGA: ENSG00000113161
COSMIC: HMGCR
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA133950441 | hmg coa reductase inhibitors | Chemical | ClinicalAnnotation, Pathway | associated | PD | 15199031, 16103896, 17563401, 18261733, 18332269, 18815589, 20403997 | |
| PA33744 | PRKAA1 | Gene | Pathway | associated | 22722338 | ||
| PA33745 | PRKAA2 | Gene | Pathway | associated | 22722338 | ||
| PA33746 | PRKAB1 | Gene | Pathway | associated | 22722338 | ||
| PA33747 | PRKAB2 | Gene | Pathway | associated | 22722338 | ||
| PA33751 | PRKAG1 | Gene | Pathway | associated | 22722338 | ||
| PA33752 | PRKAG2 | Gene | Pathway | associated | 22722338 | ||
| PA33753 | PRKAG3 | Gene | Pathway | associated | 22722338 | ||
| PA443635 | Cardiovascular Diseases | Disease | ClinicalAnnotation | associated | |||
| PA443756 | Colonic Neoplasms | Disease | ClinicalAnnotation | associated | PD | 20403997 | |
| PA444516 | Hypercholesterolemia | Disease | ClinicalAnnotation | associated | PD | 20031582, 26408409 | |
| PA448500 | atorvastatin | Chemical | ClinicalAnnotation | associated | PD | 15199031, 16103896, 17563401, 18261733, 18332269, 18815589, 20031582, 26408409 | |
| PA449688 | fluvastatin | Chemical | ClinicalAnnotation | associated | PD | 15199031, 16103896, 17563401, 18261733, 18332269, 18815589 | |
| PA450272 | lovastatin | Chemical | ClinicalAnnotation | associated | PD | 15199031, 16103896, 17563401, 18261733, 18332269, 18815589 | |
| PA451089 | pravastatin | Chemical | ClinicalAnnotation | associated | PD | 15199031, 16103896, 17563401, 18261733, 18332269, 18815589 | |
| PA451363 | simvastatin | Chemical | ClinicalAnnotation | associated | PD | 15199031, 16103896, 17563401, 18261733, 18332269, 18815589 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38233830 | 2024 | Association of NPC1L1 and HMGCR gene polymorphisms with coronary artery calcification in patients with premature triple-vessel coronary disease. | 0 |
| 38397481 | 2024 | Peroxisomal Localization of a Truncated HMG-CoA Reductase under Low Cholesterol Conditions. | 1 |
| 38233830 | 2024 | Association of NPC1L1 and HMGCR gene polymorphisms with coronary artery calcification in patients with premature triple-vessel coronary disease. | 0 |
| 38397481 | 2024 | Peroxisomal Localization of a Truncated HMG-CoA Reductase under Low Cholesterol Conditions. | 1 |
| 33297605 | 2023 | Early growth response 1 promoted the invasion of glioblastoma multiforme by elevating HMGB1. | 6 |
| 35470784 | 2023 | Effect of pH on structural dynamics of HMG-CoA reductase and binding affinity to β-sitosterol. | 3 |
| 36745799 | 2023 | Limb girdle muscular disease caused by HMGCR mutation and statin myopathy treatable with mevalonolactone. | 3 |
| 37355634 | 2023 | HMGCR gene polymorphism is associated with residual cholesterol risk in premature triple-vessel disease patients treated with moderate-intensity statins. | 1 |
| 37833739 | 2023 | Association between HMGCR, CRP, and CETP gene polymorphisms and metabolic/inflammatory serum profile in healthy adolescents. | 1 |
| 33297605 | 2023 | Early growth response 1 promoted the invasion of glioblastoma multiforme by elevating HMGB1. | 6 |
| 35470784 | 2023 | Effect of pH on structural dynamics of HMG-CoA reductase and binding affinity to β-sitosterol. | 3 |
| 36745799 | 2023 | Limb girdle muscular disease caused by HMGCR mutation and statin myopathy treatable with mevalonolactone. | 3 |
| 37355634 | 2023 | HMGCR gene polymorphism is associated with residual cholesterol risk in premature triple-vessel disease patients treated with moderate-intensity statins. | 1 |
| 37833739 | 2023 | Association between HMGCR, CRP, and CETP gene polymorphisms and metabolic/inflammatory serum profile in healthy adolescents. | 1 |
| 34806144 | 2022 | Association of 3-hydroxy-3-methylglutaryl-coenzyme A reductase gene polymorphism with obesity and lipid metabolism in children and adolescents with autism spectrum disorder. | 3 |
Citation
Dessen P
HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase)
Atlas Genet Cytogenet Oncol Haematol. 2010-08-01
Online version: http://atlasgeneticsoncology.org/gene/51597/hmgcr-(3-hydroxy-3-methylglutaryl-coa-reductase)
