VWCE (von Willebrand factor C and EGF domains)

2010-08-01  

Identity

HGNC
VWCE
LOCATION
11q12.2
LOCUSID
220001
ALIAS
URG11,VWC1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 220001
MIM: 611115
HGNC: 26487
Ensembl: ENSG00000167992

Variants:

dbSNP: 220001
ClinVar: 220001
TCGA: ENSG00000167992
COSMIC: VWCE

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167992ENST00000301770Q96DN2
ENSG00000167992ENST00000335613Q96DN2
ENSG00000167992ENST00000535599B4DS56
ENSG00000167992ENST00000535710B4DY31
ENSG00000167992ENST00000613271A0A087WVD8

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
164963482006Enhanced cell survival of Hep3B cells by the hepatitis B x antigen effector, URG11, is associated with upregulation of beta-catenin.18
194138862010URG11 promotes gastric cancer growth and invasion by activation of beta-catenin signalling pathway.7
199004062010URG11 mediates hypoxia-induced epithelial-to-mesenchymal transition by modulation of E-cadherin and beta-catenin.7
299556002018URG11 Regulates Prostate Cancer Cell Proliferation, Migration, and Invasion.4
297495202018Silencing of URG11 expression inhibits the proliferation and epithelial‑mesenchymal transition in benign prostatic hyperplasia cells via the RhoA/ROCK1 pathway.3
238281642013Association of URG11 and Twist with clinical pathological characteristics and prognosis in patients with IgA nephropathy.2
249300072014URG11 predicts poor prognosis of pancreatic cancer by enhancing epithelial-mesenchymal transition-driven invasion.2
274581012016Knockdown of Upregulated Gene 11 (URG11) Inhibits Proliferation, Invasion, and β-Catenin Expression in Non-Small Cell Lung Cancer Cells.2
265223622015[Increased expression URG11 in hepatocellular carcinoma tissues promotes the growth of hepatocellular carcinoma cells].1
308646782019URG11 promotes proliferation and induced apoptosis of LNCaP cells.0

Citation

Dessen P

VWCE (von Willebrand factor C and EGF domains)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51615/vwce-(von-willebrand-factor-c-and-egf-domains)