ATF7IP (activating transcription factor 7 interacting protein)

2010-08-01  

Identity

HGNC
LOCATION
12p13.1
LOCUSID
ALIAS
AM,ATF-IP,MCAF,MCAF1,p621
FUSION GENES

Other Information

Locus ID:

NCBI: 55729
MIM: 613644
HGNC: 20092
Ensembl: ENSG00000171681

Variants:

dbSNP: 55729
ClinVar: 55729
TCGA: ENSG00000171681
COSMIC: ATF7IP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171681ENST00000261168Q6VMQ6
ENSG00000171681ENST00000261168A0A024RAY1
ENSG00000171681ENST00000396279A8MV73
ENSG00000171681ENST00000428217F8WE35
ENSG00000171681ENST00000534828F5H2W9
ENSG00000171681ENST00000535132F5H221
ENSG00000171681ENST00000535738H0YFA3
ENSG00000171681ENST00000536279F5H6X8
ENSG00000171681ENST00000536444Q6VMQ6
ENSG00000171681ENST00000538511F5GYR7
ENSG00000171681ENST00000539057F5H1K9
ENSG00000171681ENST00000540793Q6VMQ6
ENSG00000171681ENST00000540793A0A024RAY1
ENSG00000171681ENST00000541056F5GZ10
ENSG00000171681ENST00000542508F5H3C4
ENSG00000171681ENST00000542514F5H8I0
ENSG00000171681ENST00000542967F5H502
ENSG00000171681ENST00000542991F5GZ98
ENSG00000171681ENST00000543189Q6VMQ6
ENSG00000171681ENST00000544627Q6VMQ6
ENSG00000171681ENST00000545723F5H592
ENSG00000171681ENST00000545769F5H2H9

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
PKMTs methylate histone lysinesREACTOMER-HSA-3214841

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
205438472010Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer.147
205438472010Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer.147
145360862003mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression.111
156918492005Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins.49
167574752006Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation.38
188425872008Structure of the small ubiquitin-like modifier (SUMO)-interacting motif of MBD1-containing chromatin-associated factor 1 bound to SUMO-3.33
244641302014The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.23
191061002009MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity.22
277328432016ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex.19
239358712013The transcriptional cofactor MCAF1/ATF7IP is involved in histone gene expression and cellular senescence.6

Citation

Dessen P

ATF7IP (activating transcription factor 7 interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51647/atf7ip-(activating-transcription-factor-7-interacting-protein)