ATF7IP (activating transcription factor 7 interacting protein)

2010-08-01  

Identity

HGNC
ATF7IP
LOCATION
12p13.1
LOCUSID
55729
ALIAS
AM,ATF-IP,MCAF,MCAF1,p621
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55729
MIM: 613644
HGNC: 20092
Ensembl: ENSG00000171681

Variants:

dbSNP: 55729
ClinVar: 55729
TCGA: ENSG00000171681
COSMIC: ATF7IP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171681ENST00000261168Q6VMQ6
ENSG00000171681ENST00000261168A0A024RAY1
ENSG00000171681ENST00000396279A8MV73
ENSG00000171681ENST00000428217F8WE35
ENSG00000171681ENST00000534828F5H2W9
ENSG00000171681ENST00000535132F5H221
ENSG00000171681ENST00000535738H0YFA3
ENSG00000171681ENST00000536279F5H6X8
ENSG00000171681ENST00000536444Q6VMQ6
ENSG00000171681ENST00000538511F5GYR7
ENSG00000171681ENST00000539057F5H1K9
ENSG00000171681ENST00000540793Q6VMQ6
ENSG00000171681ENST00000540793A0A024RAY1
ENSG00000171681ENST00000541056F5GZ10
ENSG00000171681ENST00000542508F5H3C4
ENSG00000171681ENST00000542514F5H8I0
ENSG00000171681ENST00000542967F5H502
ENSG00000171681ENST00000542991F5GZ98
ENSG00000171681ENST00000543189Q6VMQ6
ENSG00000171681ENST00000544627Q6VMQ6
ENSG00000171681ENST00000545723F5H592
ENSG00000171681ENST00000545769F5H2H9

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
PKMTs methylate histone lysinesREACTOMER-HSA-3214841

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
351752392022Mutational Alterations of DNA Methylation-related Genes CTCF, ZFP57, and ATF7IP Genes in Colon Cancers.0
351752392022Mutational Alterations of DNA Methylation-related Genes CTCF, ZFP57, and ATF7IP Genes in Colon Cancers.0
315766542019ATF7IP regulates SETDB1 nuclear localization and increases its ubiquitination.37
315766542019ATF7IP regulates SETDB1 nuclear localization and increases its ubiquitination.37
304526832018Mechanism suppressing H3K9 trimethylation in pluripotent stem cells and its demise by polyQ-expanded huntingtin mutations.16
304526832018Mechanism suppressing H3K9 trimethylation in pluripotent stem cells and its demise by polyQ-expanded huntingtin mutations.16
291337772017Acute Lymphoblastic Leukemia Patient with Variant ATF7IP/PDGFRB Fusion and Favorable Response to Tyrosine Kinase Inhibitor Treatment: A Case Report.7
291337772017Acute Lymphoblastic Leukemia Patient with Variant ATF7IP/PDGFRB Fusion and Favorable Response to Tyrosine Kinase Inhibitor Treatment: A Case Report.7
268136932016Characterization of the Enzymatic Activity of SETDB1 and Its 1:1 Complex with ATF7IP.10
277328432016ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex.75
268136932016Characterization of the Enzymatic Activity of SETDB1 and Its 1:1 Complex with ATF7IP.10
277328432016ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex.75
244641302014The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.43
245987292014MCAF1 and Rta-activated BZLF1 transcription in Epstein-Barr virus.5
244641302014The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.43

Citation

Dessen P

ATF7IP (activating transcription factor 7 interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51647/atf7ip-(activating-transcription-factor-7-interacting-protein)