VNN1 (vanin 1)

Identity

HGNC

VNN1

LOCATION

6q23.2

LOCUSID

8876

ALIAS

HDLCQ8,Tiff66

Other Information

Locus ID:

NCBI: 8876
MIM: 603570
HGNC: 12705
Ensembl: ENSG00000112299

Variants:

dbSNP: 8876
ClinVar: 8876
TCGA: ENSG00000112299
COSMIC: VNN1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000112299	ENST00000367928	O95497

Expression (GTEx)

0

10

20

30

40

50

60

70

80

90

100

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Metabolism	REACTOME	R-HSA-1430728
Metabolism of proteins	REACTOME	R-HSA-392499
Metabolism of vitamins and cofactors	REACTOME	R-HSA-196854
Metabolism of water-soluble vitamins and cofactors	REACTOME	R-HSA-196849
Neutrophil degranulation	REACTOME	R-HSA-6798695
Pantothenate and CoA biosynthesis	KEGG	ko00770
Pantothenate and CoA biosynthesis	KEGG	hsa00770
Post-translational modification: synthesis of GPI-anchored proteins	REACTOME	R-HSA-163125

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Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
27317936	2016	Early prediction of cisplatin-induced nephrotoxicity by urinary vanin-1 in patients with urothelial carcinoma.	14
28316092	2017	Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress.	23
28316092	2017	Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress.	23
28576495	2017	Metabolic pathway catalyzed by Vanin-1 pantetheinase plays a suppressive role in influenza virus replication in human alveolar epithelial A549 cells.	7
28576495	2017	Metabolic pathway catalyzed by Vanin-1 pantetheinase plays a suppressive role in influenza virus replication in human alveolar epithelial A549 cells.	7
30791405	2019	A Novel Biomarker for Acute Kidney Injury, Vanin-1, for Obstructive Nephropathy: A Prospective Cohort Pilot Study.	10
30791405	2019	A Novel Biomarker for Acute Kidney Injury, Vanin-1, for Obstructive Nephropathy: A Prospective Cohort Pilot Study.	10
31404995	2019	Vanin 1: Its Physiological Function and Role in Diseases.	41
31404995	2019	Vanin 1: Its Physiological Function and Role in Diseases.	41
33656956	2021	Urinary vanin-1 for predicting acute pyelonephritis in young children with urinary tract infection: a pilot study.	0

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Citation

Dessen P

VNN1 (vanin 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51651/vnn1-(vanin-1)