SLC29A3 (solute carrier family 29 member 3)

2010-09-01  

Identity

HGNC
LOCATION
10q22.1
LOCUSID
ALIAS
ENT3,HCLAP,HJCD,PHID
FUSION GENES

Other Information

Locus ID:

NCBI: 55315
MIM: 612373
HGNC: 23096
Ensembl: ENSG00000198246

Variants:

dbSNP: 55315
ClinVar: 55315
TCGA: ENSG00000198246
COSMIC: SLC29A3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198246ENST00000373189Q9BZD2
ENSG00000198246ENST00000479577A0A2R8YDR8
ENSG00000198246ENST00000642198A0A2R8Y5U2
ENSG00000198246ENST00000642772A0A2R8Y4I0
ENSG00000198246ENST00000643042A0A2R8Y863
ENSG00000198246ENST00000643619A0A2R8YDA4
ENSG00000198246ENST00000643752A0A2R8Y5R8
ENSG00000198246ENST00000644088A0A2R8Y4I0
ENSG00000198246ENST00000644591A0A2R8Y4B7
ENSG00000198246ENST00000644895A0A2R8Y4B7
ENSG00000198246ENST00000645345A0A2R8YGC2
ENSG00000198246ENST00000647524A0A2R8Y657

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of vitamins, nucleosides, and related moleculesREACTOMER-HSA-425397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membraneREACTOMER-HSA-83936

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443622Carcinoma, Non-Small-Cell LungDiseaseClinicalAnnotationassociatedPD
PA449748gemcitabineChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
381046462024Equilibrative nucleotide transporter ENT3 (SLC29A3): A unique transporter for inherited disorders and cancers.0
385462812024Identification of Coding Variants in 10q22.1 Associated with Vitiligo in the Chinese Han Population.0
381046462024Equilibrative nucleotide transporter ENT3 (SLC29A3): A unique transporter for inherited disorders and cancers.0
385462812024Identification of Coding Variants in 10q22.1 Associated with Vitiligo in the Chinese Han Population.0
377385622023Loss of function of ENT3 drives histiocytosis and inflammation through TLR-MAPK signaling.2
377385622023Loss of function of ENT3 drives histiocytosis and inflammation through TLR-MAPK signaling.2
338376342021Resolution of sclerotic lesions of dysosteosclerosis due to biallelic SLC29A3 variant in a Turkish girl.3
346576282021Phenotypic intrafamilial variability including H syndrome and Rosai-Dorfman disease associated with the same c.1088G > A mutation in the SLC29A3 gene.6
338376342021Resolution of sclerotic lesions of dysosteosclerosis due to biallelic SLC29A3 variant in a Turkish girl.3
346576282021Phenotypic intrafamilial variability including H syndrome and Rosai-Dorfman disease associated with the same c.1088G > A mutation in the SLC29A3 gene.6
327381872020MiR-1224-5p acts as a tumor suppressor via inhibiting the malignancy of rectal cancer through targeting SLC29A3.5
329447922020Pediatric recurrent Rosai-Dorfman disease with germline heterozygous SLC29A3 and somatic MAP2K1 mutations.0
327381872020MiR-1224-5p acts as a tumor suppressor via inhibiting the malignancy of rectal cancer through targeting SLC29A3.5
329447922020Pediatric recurrent Rosai-Dorfman disease with germline heterozygous SLC29A3 and somatic MAP2K1 mutations.0
305170792019A Turkish girl with H syndrome: stunted growth and development of autoimmune insulin dependent diabetes mellitus in the 6th year of diagnosis.2

Citation

Dessen P

SLC29A3 (solute carrier family 29 member 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-09-01

Online version: http://atlasgeneticsoncology.org/gene/51657