SRSF6 (serine and arginine rich splicing factor 6)

2010-09-01 Affiliation

Identity

HGNC

SRSF6

LOCATION

20q13.11

LOCUSID

6431

ALIAS

B52,HEL-S-91,SFRS6,SRP55

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6431
MIM: 601944
HGNC: 10788
Ensembl: ENSG00000124193

Variants:

dbSNP: 6431
ClinVar: 6431
TCGA: ENSG00000124193
COSMIC: SRSF6

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000124193	ENST00000244020	Q13247
ENSG00000124193	ENST00000483871	Q13247
ENSG00000124193	ENST00000662078	A0A590UK01
ENSG00000124193	ENST00000668808	A0A590UJP7
ENSG00000124193	ENST00000670741	A0A590UJK4

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Spliceosome	KEGG	ko03040
Spliceosome	KEGG	hsa03040
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
Gene Expression	REACTOME	R-HSA-74160
RNA Polymerase II Transcription	REACTOME	R-HSA-73857
RNA Polymerase II Transcription Termination	REACTOME	R-HSA-73856
Cleavage of Growing Transcript in the Termination Region	REACTOME	R-HSA-109688
Processing of Capped Intron-Containing Pre-mRNA	REACTOME	R-HSA-72203
mRNA Splicing	REACTOME	R-HSA-72172
mRNA Splicing - Major Pathway	REACTOME	R-HSA-72163
mRNA Splicing - Minor Pathway	REACTOME	R-HSA-72165
mRNA 3'-end processing	REACTOME	R-HSA-72187
Transport of Mature Transcript to Cytoplasm	REACTOME	R-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing Transcript	REACTOME	R-HSA-159236

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36620874	2023	Poison cassette exon splicing of SRSF6 regulates nuclear speckle dispersal and the response to hypoxia.	9
36807382	2023	Genetic compensation response could exist in colorectal cancer: UPF3A upregulates the oncogenic homologue gene SRSF3 expression corresponding to SRSF6 to promote colorectal cancer metastasis.	2
36620874	2023	Poison cassette exon splicing of SRSF6 regulates nuclear speckle dispersal and the response to hypoxia.	9
36807382	2023	Genetic compensation response could exist in colorectal cancer: UPF3A upregulates the oncogenic homologue gene SRSF3 expression corresponding to SRSF6 to promote colorectal cancer metastasis.	2
34665708	2022	A candidate gene study reveals association between a variant of the SRp55 splicing factor gene and systemic sclerosis.	0
34665708	2022	A candidate gene study reveals association between a variant of the SRp55 splicing factor gene and systemic sclerosis.	0
33050987	2021	Relative strength of 5' splice-site strength defines functions of SRSF2 and SRSF6 in alternative splicing of Bcl-x pre-mRNA.	3
33376132	2021	The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells.	11
33397371	2021	LncRNA CRNDE attenuates chemoresistance in gastric cancer via SRSF6-regulated alternative splicing of PICALM.	75
33905374	2021	Splicing factor SRSF6 mediates pleural fibrosis.	5
34614409	2021	DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing.	28
33050987	2021	Relative strength of 5' splice-site strength defines functions of SRSF2 and SRSF6 in alternative splicing of Bcl-x pre-mRNA.	3
33376132	2021	The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells.	11
33397371	2021	LncRNA CRNDE attenuates chemoresistance in gastric cancer via SRSF6-regulated alternative splicing of PICALM.	75
33905374	2021	Splicing factor SRSF6 mediates pleural fibrosis.	5

Citation

Dessen P

SRSF6 (serine and arginine rich splicing factor 6)

Atlas Genet Cytogenet Oncol Haematol. 2010-09-01

Online version: http://atlasgeneticsoncology.org/gene/51664/srsf6-(serine-and-arginine-rich-splicing-factor-6)