Identity
HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
BTBD12,FANCP,MUS312
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 84464
MIM: 613278
HGNC: 23845
Ensembl: ENSG00000188827
Variants:
dbSNP: 84464
ClinVar: 84464
TCGA: ENSG00000188827
COSMIC: SLX4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000188827 | ENST00000294008 | Q8IY92 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37059091 | 2023 | Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair. | 8 |
| 37059091 | 2023 | Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair. | 8 |
| 33347546 | 2021 | SLX4-XPF mediates DNA damage responses to replication stress induced by DNA-protein interactions. | 8 |
| 33596761 | 2021 | Coordinated roles of SLX4 and MutSβ in DNA repair and the maintenance of genome stability. | 13 |
| 33945829 | 2021 | PARP1 modulates telomere sister chromatid exchange and telomere length homeostasis by regulating telomere localization of SLX4 in U2OS cells. | 1 |
| 34272385 | 2021 | Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage. | 9 |
| 34706224 | 2021 | RNF168 E3 ligase participates in ubiquitin signaling and recruitment of SLX4 during DNA crosslink repair. | 5 |
| 33347546 | 2021 | SLX4-XPF mediates DNA damage responses to replication stress induced by DNA-protein interactions. | 8 |
| 33596761 | 2021 | Coordinated roles of SLX4 and MutSβ in DNA repair and the maintenance of genome stability. | 13 |
| 33945829 | 2021 | PARP1 modulates telomere sister chromatid exchange and telomere length homeostasis by regulating telomere localization of SLX4 in U2OS cells. | 1 |
| 34272385 | 2021 | Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage. | 9 |
| 34706224 | 2021 | RNF168 E3 ligase participates in ubiquitin signaling and recruitment of SLX4 during DNA crosslink repair. | 5 |
| 32398829 | 2020 | SLX4 interacts with RTEL1 to prevent transcription-mediated DNA replication perturbations. | 21 |
| 32398829 | 2020 | SLX4 interacts with RTEL1 to prevent transcription-mediated DNA replication perturbations. | 21 |
| 30692206 | 2019 | RAD52 and SLX4 act nonepistatically to ensure telomere stability during alternative telomere lengthening. | 69 |
Citation
Dessen P
SLX4 (SLX4 structure-specific endonuclease subunit)
Atlas Genet Cytogenet Oncol Haematol. 2010-09-01
Online version: http://atlasgeneticsoncology.org/gene/51673/slx4-(slx4-structure-specific-endonuclease-subunit)
