PTGR1 (prostaglandin reductase 1)

2010-09-01  

Identity

HGNC
PTGR1
LOCATION
9q31.3
LOCUSID
22949
ALIAS
DIG-1,LTB4DH,PGR1,ZADH3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 22949
MIM: 601274
HGNC: 18429
Ensembl: ENSG00000106853

Variants:

dbSNP: 22949
ClinVar: 22949
TCGA: ENSG00000106853
COSMIC: PTGR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106853ENST00000309195Q14914
ENSG00000106853ENST00000374324F6XGT7
ENSG00000106853ENST00000407693Q14914
ENSG00000106853ENST00000422125Q5JVP2
ENSG00000106853ENST00000466771F2Z3J9
ENSG00000106853ENST00000538962Q14914

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of Leukotrienes (LT) and Eoxins (EX)REACTOMER-HSA-2142691
Synthesis of Lipoxins (LX)REACTOMER-HSA-2142700

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384136642024The human PTGR1 gene expression is controlled by TE-derived Z-DNA forming sequence cooperating with miR-6867-5p.0
384136642024The human PTGR1 gene expression is controlled by TE-derived Z-DNA forming sequence cooperating with miR-6867-5p.0
379105372023PTGR1 is involved in cell proliferation in thoracic ossification of the ligamentum flavum.0
379105372023PTGR1 is involved in cell proliferation in thoracic ossification of the ligamentum flavum.0
303369812018Role of leukotriene B4 12-hydroxydehydrogenase in α-galactosylceramide-pulsed dendritic cell therapy for non-small cell lung cancer.0
303369812018Role of leukotriene B4 12-hydroxydehydrogenase in α-galactosylceramide-pulsed dendritic cell therapy for non-small cell lung cancer.0
280885502017Novel involvement of miR-522-3p in high-mobility group box 1-induced prostaglandin reductase 1 expression and reduction of phagocytosis.11
280885502017Novel involvement of miR-522-3p in high-mobility group box 1-induced prostaglandin reductase 1 expression and reduction of phagocytosis.11
251791602015Induction of complementary function reductase enzymes in colon cancer cells by dithiole-3-thione versus sodium selenite.4
251791602015Induction of complementary function reductase enzymes in colon cancer cells by dithiole-3-thione versus sodium selenite.4
238781982013Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase.38
238781982013Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase.38
195954722010Restoration of leukotriene B(4)-12-hydroxydehydrogenase/15- oxo-prostaglandin 13-reductase (LTBDH/PGR) expression inhibits lung cancer growth in vitro and in vivo.9
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
208045022010A set of genes associated with the interferon-γ response of lung cancer patients undergoing α-galactosylceramide-pulsed dendritic cell therapy.6

Citation

Dessen P

PTGR1 (prostaglandin reductase 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-09-01

Online version: http://atlasgeneticsoncology.org/gene/51675/ptgr1-(prostaglandin-reductase-1)