TNPO2 (transportin 2)

2010-10-01  

Identity

HGNC
TNPO2
LOCATION
19p13.13
LOCUSID
30000
ALIAS
IPO3,KPNB2B,TRN2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 30000
MIM: 603002
HGNC: 19998
Ensembl: ENSG00000105576

Variants:

dbSNP: 30000
ClinVar: 30000
TCGA: ENSG00000105576
COSMIC: TNPO2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105576ENST00000356861O14787
ENSG00000105576ENST00000356861A0A024R7F7
ENSG00000105576ENST00000425528O14787
ENSG00000105576ENST00000450764O14787
ENSG00000105576ENST00000450764A0A024R7F7
ENSG00000105576ENST00000585886A0A075B780
ENSG00000105576ENST00000586775K7ESC1
ENSG00000105576ENST00000587654K7ESC1
ENSG00000105576ENST00000588216O14787
ENSG00000105576ENST00000588216A0A024R7F7
ENSG00000105576ENST00000588491K7ELC3
ENSG00000105576ENST00000589149K7ESG1
ENSG00000105576ENST00000589337K7ENW1
ENSG00000105576ENST00000589572K7ESJ3
ENSG00000105576ENST00000590781K7EMA3
ENSG00000105576ENST00000592287O14787

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
343147052021TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila.18
343147052021TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila.18
331226992020Transportin-2 plays a critical role in nucleocytoplasmic shuttling of oestrogen receptor-α.5
331226992020Transportin-2 plays a critical role in nucleocytoplasmic shuttling of oestrogen receptor-α.5
316054492019TNPO2 operates downstream of DYNC1I1 and promotes gastric cancer cell proliferation and inhibits apoptosis.8
316054492019TNPO2 operates downstream of DYNC1I1 and promotes gastric cancer cell proliferation and inhibits apoptosis.8
260602532015IPO3-mediated Nonclassical Nuclear Import of NF-κB Essential Modulator (NEMO) Drives DNA Damage-dependent NF-κB Activation.13
260602532015IPO3-mediated Nonclassical Nuclear Import of NF-κB Essential Modulator (NEMO) Drives DNA Damage-dependent NF-κB Activation.13
247800992014Transportin-1 and Transportin-2: protein nuclear import and beyond.60
247800992014Transportin-1 and Transportin-2: protein nuclear import and beyond.60
216463542011Transportin 2 regulates apoptosis through the RNA-binding protein HuR.11
216463542011Transportin 2 regulates apoptosis through the RNA-binding protein HuR.11
206066252010ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import.417
206066252010ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import.417
169017872006Rules for nuclear localization sequence recognition by karyopherin beta 2.282

Citation

Dessen P

TNPO2 (transportin 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51677/tnpo2-(transportin-2)