PICK1 (protein interacting with PRKCA 1)

2010-10-01  

Identity

HGNC
LOCATION
22q13.1
LOCUSID
ALIAS
PICK,PRKCABP
FUSION GENES

Other Information

Locus ID:

NCBI: 9463
MIM: 605926
HGNC: 9394
Ensembl: ENSG00000100151

Variants:

dbSNP: 9463
ClinVar: 9463
TCGA: ENSG00000100151
COSMIC: PICK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100151ENST00000356976Q9NRD5
ENSG00000100151ENST00000356976A0A024R1J5
ENSG00000100151ENST00000404072Q9NRD5
ENSG00000100151ENST00000404072A0A024R1J5
ENSG00000100151ENST00000424694F6V107
ENSG00000100151ENST00000426258E7EX80
ENSG00000100151ENST00000432756E7EX80
ENSG00000100151ENST00000435166F6VY12
ENSG00000100151ENST00000437453F6V3V1
ENSG00000100151ENST00000445628F6TII1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Glutamate Binding, Activation of AMPA Receptors and Synaptic PlasticityREACTOMER-HSA-399721
Trafficking of AMPA receptorsREACTOMER-HSA-399719
Trafficking of GluR2-containing AMPA receptorsREACTOMER-HSA-416993
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA446876Substance-Related DisordersDiseaseClinicalAnnotationassociatedPD17606663
PA447215Psychotic DisordersDiseaseClinicalAnnotationassociatedPD17606663
PA450403methamphetamineChemicalClinicalAnnotationassociatedPD17606663

References

Pubmed IDYearTitleCitations
384277372024Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment.0
384277372024Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment.0
380015352023Multi-omics study identifies that PICK1 deficiency causes male infertility by inhibiting vesicle trafficking in Sertoli cells.0
380015352023Multi-omics study identifies that PICK1 deficiency causes male infertility by inhibiting vesicle trafficking in Sertoli cells.0
350773982022Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis.4
354559352022The Scaffold Protein PICK1 as a Target in Chronic Pain.5
350773982022Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis.4
354559352022The Scaffold Protein PICK1 as a Target in Chronic Pain.5
334998512021Association of PICK1 and BDNF variations with increased risk of methamphetamine dependence among Iranian population: a case-control study.0
336601482021Protein interacting with C-kinase 1 is involved in epithelial-mesenchymal transformation and suppresses progress of gastric cancer.3
343076722021PICK1 Deficiency Exacerbates Sepsis-Associated Acute Kidney Injury.3
334998512021Association of PICK1 and BDNF variations with increased risk of methamphetamine dependence among Iranian population: a case-control study.0
336601482021Protein interacting with C-kinase 1 is involved in epithelial-mesenchymal transformation and suppresses progress of gastric cancer.3
343076722021PICK1 Deficiency Exacerbates Sepsis-Associated Acute Kidney Injury.3
317405292020The Host GTPase Arf1 and Its Effectors AP1 and PICK1 Stimulate Actin Polymerization and Exocytosis To Promote Entry of Listeria monocytogenes.5

Citation

Dessen P

PICK1 (protein interacting with PRKCA 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51687/pick1-(protein-interacting-with-prkca-1)