Identity
HGNC
LOCATION
14q22.1
LOCUSID
ALIAS
KIND2,MIG2,PLEKHC1,UNC112,UNC112B,mig-2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10979
MIM: 607746
HGNC: 15767
Ensembl: ENSG00000073712
Variants:
dbSNP: 10979
ClinVar: 10979
TCGA: ENSG00000073712
COSMIC: FERMT2
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Cell-Cell communication | REACTOME | R-HSA-1500931 |
| Cell junction organization | REACTOME | R-HSA-446728 |
| Cell-extracellular matrix interactions | REACTOME | R-HSA-446353 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37357349 | 2024 | FERMT2 upregulation in CAFs enhances EMT of OSCC and M2 macrophage polarization. | 1 |
| 38084837 | 2024 | Kindlin-2 regulates colonic cancer stem-like cells survival and self-renewal via Wnt/β-catenin mediated pathway. | 3 |
| 37357349 | 2024 | FERMT2 upregulation in CAFs enhances EMT of OSCC and M2 macrophage polarization. | 1 |
| 38084837 | 2024 | Kindlin-2 regulates colonic cancer stem-like cells survival and self-renewal via Wnt/β-catenin mediated pathway. | 3 |
| 37142218 | 2023 | Parkin ubiquitination of Kindlin-2 enables mitochondria-associated metastasis suppression. | 1 |
| 37480504 | 2023 | Kindlin-2 controls angiogenesis through modulating Notch1 signaling. | 1 |
| 37142218 | 2023 | Parkin ubiquitination of Kindlin-2 enables mitochondria-associated metastasis suppression. | 1 |
| 37480504 | 2023 | Kindlin-2 controls angiogenesis through modulating Notch1 signaling. | 1 |
| 35450413 | 2022 | Kindlin-2 Promotes Chondrogenesis and Ameliorates IL-1beta-Induced Inflammation in Chondrocytes Cocultured with BMSCs in the Direct Contact Coculture System. | 2 |
| 35595729 | 2022 | Kindlin-2 promotes Src-mediated tyrosine phosphorylation of androgen receptor and contributes to breast cancer progression. | 4 |
| 36480537 | 2022 | Alzheimer's risk factor FERMT2 promotes the progression of colorectal carcinoma via Wnt/β-catenin signaling pathway and contributes to the negative correlation between Alzheimer and cancer. | 3 |
| 35450413 | 2022 | Kindlin-2 Promotes Chondrogenesis and Ameliorates IL-1beta-Induced Inflammation in Chondrocytes Cocultured with BMSCs in the Direct Contact Coculture System. | 2 |
| 35595729 | 2022 | Kindlin-2 promotes Src-mediated tyrosine phosphorylation of androgen receptor and contributes to breast cancer progression. | 4 |
| 36480537 | 2022 | Alzheimer's risk factor FERMT2 promotes the progression of colorectal carcinoma via Wnt/β-catenin signaling pathway and contributes to the negative correlation between Alzheimer and cancer. | 3 |
| 33125708 | 2021 | miRNA-200c-3p promotes endothelial to mesenchymal transition and neointimal hyperplasia in artery bypass grafts. | 16 |
Citation
Dessen P
FERMT2 (FERM domain containing kindlin 2)
Atlas Genet Cytogenet Oncol Haematol. 2010-10-01
Online version: http://atlasgeneticsoncology.org/gene/51688/fermt2-(ferm-domain-containing-kindlin-2)
