CREB3 (cAMP responsive element binding protein 3)

2010-10-01  

Identity

HGNC
LOCATION
9p13.3
LOCUSID
ALIAS
LUMAN,LZIP,sLZIP
FUSION GENES

Other Information

Locus ID:

NCBI: 10488
MIM: 606443
HGNC: 2347
Ensembl: ENSG00000107175

Variants:

dbSNP: 10488
ClinVar: 10488
TCGA: ENSG00000107175
COSMIC: CREB3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107175ENST00000353704O43889

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
MelanogenesisKEGGko04916
Huntington's diseaseKEGGko05016
Prostate cancerKEGGko05215
MelanogenesisKEGGhsa04916
Huntington's diseaseKEGGhsa05016
Prostate cancerKEGGhsa05215
Vasopressin-regulated water reabsorptionKEGGko04962
Vasopressin-regulated water reabsorptionKEGGhsa04962
Cholinergic synapseKEGGhsa04725
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Cocaine addictionKEGGhsa05030
Cocaine addictionKEGGko05030
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Hepatitis BKEGGhsa05161
Insulin secretionKEGGhsa04911
Estrogen signaling pathwayKEGGhsa04915
Estrogen signaling pathwayKEGGko04915
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
Aldosterone synthesis and secretionKEGGhsa04925
Insulin resistanceKEGGhsa04931
Aldosterone synthesis and secretionKEGGko04925
Longevity regulating pathwayKEGGhsa04211

References

Pubmed IDYearTitleCitations
169401802006Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element.52
241851782013A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens.51
121381762002Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis.42
183910222008A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of the unfolded protein response.29
181892802008Lithium response and genetic variation in the CREB family of genes.27
204735472010HDAC3 selectively represses CREB3-mediated transcription and migration of metastatic breast cancer cells.26
309401512019Circular RNA circTADA2A promotes osteosarcoma progression and metastasis by sponging miR-203a-3p and regulating CREB3 expression.25
122711262002An activation domain in the C-terminal subunit of HCF-1 is important for transactivation by VP16 and LZIP.17
205469002010DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation.17
150015592004Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines.15

Citation

Dessen P

CREB3 (cAMP responsive element binding protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51721/creb3-(camp-responsive-element-binding-protein-3)