CREB3 (cAMP responsive element binding protein 3)

2010-10-01  

Identity

HGNC
CREB3
LOCATION
9p13.3
LOCUSID
10488
ALIAS
LUMAN,LZIP,sLZIP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10488
MIM: 606443
HGNC: 2347
Ensembl: ENSG00000107175

Variants:

dbSNP: 10488
ClinVar: 10488
TCGA: ENSG00000107175
COSMIC: CREB3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107175ENST00000353704O43889

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MelanogenesisKEGGko04916
Huntington's diseaseKEGGko05016
Prostate cancerKEGGko05215
MelanogenesisKEGGhsa04916
Huntington's diseaseKEGGhsa05016
Prostate cancerKEGGhsa05215
Vasopressin-regulated water reabsorptionKEGGko04962
Vasopressin-regulated water reabsorptionKEGGhsa04962
Cholinergic synapseKEGGhsa04725
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Cocaine addictionKEGGhsa05030
Cocaine addictionKEGGko05030
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Hepatitis BKEGGhsa05161
Insulin secretionKEGGhsa04911
Estrogen signaling pathwayKEGGhsa04915
Estrogen signaling pathwayKEGGko04915
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
Aldosterone synthesis and secretionKEGGhsa04925
Insulin resistanceKEGGhsa04931
Aldosterone synthesis and secretionKEGGko04925
Longevity regulating pathwayKEGGhsa04211

References

Pubmed IDYearTitleCitations
384809022024Dysregulated CREB3 cleavage at the nuclear membrane induces karyoptosis-mediated cell death.0
384809022024Dysregulated CREB3 cleavage at the nuclear membrane induces karyoptosis-mediated cell death.0
357466432022CREB3 Plays an Important Role in HPSE-Facilitated HSV-1 Release in Human Corneal Epithelial Cells.3
357466432022CREB3 Plays an Important Role in HPSE-Facilitated HSV-1 Release in Human Corneal Epithelial Cells.3
333556432021Role of small leucine zipper protein in hepatic gluconeogenesis and metabolic disorder.0
338033452021Comparative Analysis of CREB3 and CREB3L2 Protein Expression in HEK293 Cells.2
333556432021Role of small leucine zipper protein in hepatic gluconeogenesis and metabolic disorder.0
338033452021Comparative Analysis of CREB3 and CREB3L2 Protein Expression in HEK293 Cells.2
319416002020The stability of CREB3/Luman is regulated by protein kinase CK2 phosphorylation.2
319416002020The stability of CREB3/Luman is regulated by protein kinase CK2 phosphorylation.2
309401512019Circular RNA circTADA2A promotes osteosarcoma progression and metastasis by sponging miR-203a-3p and regulating CREB3 expression.141
312916992019Regulation of the ER-bound transcription factor Luman/CREB3 in HEK293 cells.2
316128632019Knockdown of CREB3 activates endoplasmic reticulum stress and induces apoptosis in glioblastoma.4
309401512019Circular RNA circTADA2A promotes osteosarcoma progression and metastasis by sponging miR-203a-3p and regulating CREB3 expression.141
312916992019Regulation of the ER-bound transcription factor Luman/CREB3 in HEK293 cells.2

Citation

Dessen P

CREB3 (cAMP responsive element binding protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51721/meetings/deep-insight-explorer/hgnc