Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 152831
MIM: 611135
HGNC: 15527
Ensembl: ENSG00000134962
Variants:
dbSNP: 152831
ClinVar: 152831
TCGA: ENSG00000134962
COSMIC: KLB
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000134962 | ENST00000257408 | Q86Z14 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443309 | Alcoholism | Disease | ClinicalAnnotation | associated | PD | ||
| PA448073 | ethanol | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38141848 | 2024 | Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis via β-Klotho and perilipin 2. | 1 |
| 39048709 | 2024 | Development and validation of a predictive model based on β-Klotho for head and neck squamous cell carcinoma. | 0 |
| 38141848 | 2024 | Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis via β-Klotho and perilipin 2. | 1 |
| 39048709 | 2024 | Development and validation of a predictive model based on β-Klotho for head and neck squamous cell carcinoma. | 0 |
| 37019912 | 2023 | KLB and NOX4 expression levels as potential blood-based transcriptional biomarkers of physical activity in children. | 1 |
| 37582861 | 2023 | Klotho-beta attenuates Rab8a-mediated exosome regulation and promotes prostate cancer progression. | 1 |
| 37660729 | 2023 | FGF21 prevents neuronal cell ferroptosis after spinal cord injury by activating the FGFR1/β-Klotho pathway. | 2 |
| 37019912 | 2023 | KLB and NOX4 expression levels as potential blood-based transcriptional biomarkers of physical activity in children. | 1 |
| 37582861 | 2023 | Klotho-beta attenuates Rab8a-mediated exosome regulation and promotes prostate cancer progression. | 1 |
| 37660729 | 2023 | FGF21 prevents neuronal cell ferroptosis after spinal cord injury by activating the FGFR1/β-Klotho pathway. | 2 |
| 35793534 | 2022 | Role of β-Klotho and Malondialdehyde in Metabolic Disorders, HIV Infection, and Antiretroviral Therapy. | 0 |
| 35793534 | 2022 | Role of β-Klotho and Malondialdehyde in Metabolic Disorders, HIV Infection, and Antiretroviral Therapy. | 0 |
| 33640795 | 2021 | The KLB rs17618244 gene variant is associated with fibrosing MAFLD by promoting hepatic stellate cell activation. | 8 |
| 34158479 | 2021 | KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease. | 19 |
| 33640795 | 2021 | The KLB rs17618244 gene variant is associated with fibrosing MAFLD by promoting hepatic stellate cell activation. | 8 |
Citation
Dessen P
KLB (klotho beta)
Atlas Genet Cytogenet Oncol Haematol. 2010-10-01
Online version: http://atlasgeneticsoncology.org/gene/51724/klb-(klotho-beta)
