ACER2 (alkaline ceramidase 2)

2010-10-01  

Identity

HGNC
ACER2
LOCATION
9p22.1
LOCUSID
340485
ALIAS
ALKCDase2,ASAH3L
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 340485
MIM: 613492
HGNC: 23675
Ensembl: ENSG00000177076

Variants:

dbSNP: 340485
ClinVar: 340485
TCGA: ENSG00000177076
COSMIC: ACER2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177076ENST00000340967Q5QJU3

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Sphingolipid metabolismKEGGko00600
Sphingolipid metabolismKEGGhsa00600
Metabolic pathwaysKEGGhsa01100
Sphingosine biosynthesisKEGGM00099
Sphingosine biosynthesisKEGGhsa_M00099
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Sphingolipid de novo biosynthesisREACTOMER-HSA-1660661

References

Pubmed IDYearTitleCitations
365138722023miR-196a-5p Correlates with Chronic Atrophic Gastritis Progression to Gastric Cancer and Induces Malignant Biological Behaviors of Gastric Cancer Cells by Targeting ACER2.1
365138722023miR-196a-5p Correlates with Chronic Atrophic Gastritis Progression to Gastric Cancer and Induces Malignant Biological Behaviors of Gastric Cancer Cells by Targeting ACER2.1
330934512020TIMELESS regulates sphingolipid metabolism and tumor cell growth through Sp1/ACER2/S1P axis in ER-positive breast cancer.19
330934512020TIMELESS regulates sphingolipid metabolism and tumor cell growth through Sp1/ACER2/S1P axis in ER-positive breast cancer.19
292299902018Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2.32
292299902018Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2.32
282941572017Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation.21
282941572017Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation.21
269430392016Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response.27
269430392016Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response.27
247089962014Regulation of alkaline ceramidase activity by the c-Src-mediated pathway.2
247089962014Regulation of alkaline ceramidase activity by the c-Src-mediated pathway.2
200898562010Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2).37
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
206280552010Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells.30

Citation

Dessen P

ACER2 (alkaline ceramidase 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51740/acer2-(alkaline-ceramidase-2)