MAOA (monoamine oxidase A)

2010-11-01  

Identity

HGNC
MAOA
LOCATION
Xp11.3
LOCUSID
4128
ALIAS
BRNRS,MAO-A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4128
MIM: 309850
HGNC: 6833
Ensembl: ENSG00000189221

Variants:

dbSNP: 4128
ClinVar: 4128
TCGA: ENSG00000189221
COSMIC: MAOA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000189221ENST00000338702P21397
ENSG00000189221ENST00000338702Q53YE7
ENSG00000189221ENST00000542639P21397

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycine, serine and threonine metabolismKEGGko00260
Arginine and proline metabolismKEGGko00330
Histidine metabolismKEGGko00340
Tyrosine metabolismKEGGko00350
Phenylalanine metabolismKEGGko00360
Tryptophan metabolismKEGGko00380
Drug metabolism - cytochrome P450KEGGko00982
Glycine, serine and threonine metabolismKEGGhsa00260
Arginine and proline metabolismKEGGhsa00330
Histidine metabolismKEGGhsa00340
Tyrosine metabolismKEGGhsa00350
Phenylalanine metabolismKEGGhsa00360
Tryptophan metabolismKEGGhsa00380
Drug metabolism - cytochrome P450KEGGhsa00982
Metabolic pathwaysKEGGhsa01100
GABA biosynthesis, eukaryotes, putrescine => GABAKEGGhsa_M00135
GABA biosynthesis, eukaryotes, putrescine => GABAKEGGM00135
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Serotonergic synapseKEGGhsa04726
Cocaine addictionKEGGhsa05030
Cocaine addictionKEGGko05030
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Release CycleREACTOMER-HSA-112310
Norepinephrine Neurotransmitter Release CycleREACTOMER-HSA-181430
Neurotransmitter Clearance In The Synaptic CleftREACTOMER-HSA-112311
Dopamine clearance from the synaptic cleftREACTOMER-HSA-379401
Enzymatic degradation of dopamine by COMTREACTOMER-HSA-379397
Enzymatic degradation of Dopamine by monoamine oxidaseREACTOMER-HSA-379398
Serotonin clearance from the synaptic cleftREACTOMER-HSA-380615
Metabolism of serotoninREACTOMER-HSA-380612
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Amine Oxidase reactionsREACTOMER-HSA-140179
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOBREACTOMER-HSA-141333
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
121616582002Role of genotype in the cycle of violence in maltreated children.698
195069062009Candidate gene studies of ADHD: a meta-analytic review.263
168019532006MAOA, maltreatment, and gene-environment interaction predicting children's mental health: new evidence and a meta-analysis.248
168019532006MAOA, maltreatment, and gene-environment interaction predicting children's mental health: new evidence and a meta-analysis.248
168943952006The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes.153
152414352004Gene-environment interaction analysis of serotonin system markers with adolescent depression.151
192474742009Genome-wide and candidate gene association study of cigarette smoking behaviors.125
127736162003Mapping the genetic variation of executive attention onto brain activity.101
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
203517142011Poor replication of candidate genes for major depressive disorder using genome-wide association data.92

Citation

Dessen P

MAOA (monoamine oxidase A)

Atlas Genet Cytogenet Oncol Haematol. 2010-11-01

Online version: http://atlasgeneticsoncology.org/gene/51747/maoa-(monoamine-oxidase-a)