MAOA (monoamine oxidase A)

2010-11-01 Affiliation

Identity

HGNC

MAOA

LOCATION

Xp11.3

LOCUSID

4128

ALIAS

BRNRS,MAO-A

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4128
MIM: 309850
HGNC: 6833
Ensembl: ENSG00000189221

Variants:

dbSNP: 4128
ClinVar: 4128
TCGA: ENSG00000189221
COSMIC: MAOA

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000189221	ENST00000338702	P21397
ENSG00000189221	ENST00000338702	Q53YE7
ENSG00000189221	ENST00000542639	P21397

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glycine, serine and threonine metabolism	KEGG	ko00260
Arginine and proline metabolism	KEGG	ko00330
Histidine metabolism	KEGG	ko00340
Tyrosine metabolism	KEGG	ko00350
Phenylalanine metabolism	KEGG	ko00360
Tryptophan metabolism	KEGG	ko00380
Drug metabolism - cytochrome P450	KEGG	ko00982
Glycine, serine and threonine metabolism	KEGG	hsa00260
Arginine and proline metabolism	KEGG	hsa00330
Histidine metabolism	KEGG	hsa00340
Tyrosine metabolism	KEGG	hsa00350
Phenylalanine metabolism	KEGG	hsa00360
Tryptophan metabolism	KEGG	hsa00380
Drug metabolism - cytochrome P450	KEGG	hsa00982
Metabolic pathways	KEGG	hsa01100
GABA biosynthesis, eukaryotes, putrescine => GABA	KEGG	hsa_M00135
GABA biosynthesis, eukaryotes, putrescine => GABA	KEGG	M00135
Dopaminergic synapse	KEGG	ko04728
Dopaminergic synapse	KEGG	hsa04728
Serotonergic synapse	KEGG	hsa04726
Cocaine addiction	KEGG	hsa05030
Cocaine addiction	KEGG	ko05030
Amphetamine addiction	KEGG	hsa05031
Amphetamine addiction	KEGG	ko05031
Alcoholism	KEGG	hsa05034
Alcoholism	KEGG	ko05034
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Release Cycle	REACTOME	R-HSA-112310
Norepinephrine Neurotransmitter Release Cycle	REACTOME	R-HSA-181430
Neurotransmitter Clearance In The Synaptic Cleft	REACTOME	R-HSA-112311
Dopamine clearance from the synaptic cleft	REACTOME	R-HSA-379401
Enzymatic degradation of dopamine by COMT	REACTOME	R-HSA-379397
Enzymatic degradation of Dopamine by monoamine oxidase	REACTOME	R-HSA-379398
Serotonin clearance from the synaptic cleft	REACTOME	R-HSA-380615
Metabolism of serotonin	REACTOME	R-HSA-380612
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Metabolism	REACTOME	R-HSA-1430728
Biological oxidations	REACTOME	R-HSA-211859
Phase 1 - Functionalization of compounds	REACTOME	R-HSA-211945
Amine Oxidase reactions	REACTOME	R-HSA-140179
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB	REACTOME	R-HSA-141333
Interleukin-4 and 13 signaling	REACTOME	R-HSA-6785807

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37507512	2024	MAOA methylation is associated with impulsive and antisocial behaviour: dependence on allelic variation, family environment and diet.	0
38198753	2024	Cardiac monoamine oxidase-A inhibition protects against catecholamine-induced ventricular arrhythmias via enhanced diastolic calcium control.	2
38349393	2024	Targeting monoamine oxidase A: a strategy for inhibiting tumor growth with both immune checkpoint inhibitors and immune modulators.	0
37507512	2024	MAOA methylation is associated with impulsive and antisocial behaviour: dependence on allelic variation, family environment and diet.	0
38198753	2024	Cardiac monoamine oxidase-A inhibition protects against catecholamine-induced ventricular arrhythmias via enhanced diastolic calcium control.	2
38349393	2024	Targeting monoamine oxidase A: a strategy for inhibiting tumor growth with both immune checkpoint inhibitors and immune modulators.	0
36259534	2023	Maternal Education Potentially Moderates the MAOA uVNTR Effects on Externalizing Behavior in Black South African Children.	0
36573644	2023	Effect of MAOA DNA Methylation on Human in Vivo Protein Expression Measured by [11C]harmine Positron Emission Tomography.	0
37202909	2023	Association of two variable number of tandem repeats in the monoamine oxidase A gene promoter with suicide completion: The present study and meta-analysis.	1
37249744	2023	MAOA suppresses the growth of gastric cancer by interacting with NDRG1 and regulating the Warburg effect through the PI3K/AKT/mTOR pathway.	4
37322010	2023	Impact of genetic variants within serotonin turnover enzymes on human cerebral monoamine oxidase A in vivo.	3
37403079	2023	High monoamine oxidase a expression predicts poor prognosis for prostate cancer patients.	0
36259534	2023	Maternal Education Potentially Moderates the MAOA uVNTR Effects on Externalizing Behavior in Black South African Children.	0
36573644	2023	Effect of MAOA DNA Methylation on Human in Vivo Protein Expression Measured by [11C]harmine Positron Emission Tomography.	0
37202909	2023	Association of two variable number of tandem repeats in the monoamine oxidase A gene promoter with suicide completion: The present study and meta-analysis.	1

Citation

Dessen P

MAOA (monoamine oxidase A)

Atlas Genet Cytogenet Oncol Haematol. 2010-11-01

Online version: http://atlasgeneticsoncology.org/gene/51747/maoa-(monoamine-oxidase-a)