Identity
HGNC
LOCATION
17q21.32
LOCUSID
ALIAS
HEL-S-81p,SCAP1,SKAP55
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8631
MIM: 604969
HGNC: 15605
Ensembl: ENSG00000141293
Variants:
dbSNP: 8631
ClinVar: 8631
TCGA: ENSG00000141293
COSMIC: SKAP1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Rap1 signaling pathway | KEGG | hsa04015 |
| Rap1 signaling pathway | KEGG | ko04015 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36908940 | 2023 | Splicing annotation of endometrial cancer GWAS risk loci reveals potentially causal variants and supports a role for NF1 and SKAP1 as susceptibility genes. | 2 |
| 37511629 | 2023 | SKAP1 Is a Novel Biomarker and Therapeutic Target for Gastric Cancer: Evidence from Expression, Functional, and Bioinformatic Analyses. | 0 |
| 36908940 | 2023 | Splicing annotation of endometrial cancer GWAS risk loci reveals potentially causal variants and supports a role for NF1 and SKAP1 as susceptibility genes. | 2 |
| 37511629 | 2023 | SKAP1 Is a Novel Biomarker and Therapeutic Target for Gastric Cancer: Evidence from Expression, Functional, and Bioinformatic Analyses. | 0 |
| 35538197 | 2022 | THUMPD3-AS1 facilitates cell growth and aggressiveness by the miR-218-5p/SKAP1 axis in colorectal cancer. | 5 |
| 35538197 | 2022 | THUMPD3-AS1 facilitates cell growth and aggressiveness by the miR-218-5p/SKAP1 axis in colorectal cancer. | 5 |
| 34295339 | 2021 | The Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events. | 10 |
| 34295339 | 2021 | The Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events. | 10 |
| 28052935 | 2017 | D120 and K152 within the PH Domain of T Cell Adapter SKAP55 Regulate Plasma Membrane Targeting of SKAP55 and LFA-1 Affinity Modulation in Human T Lymphocytes. | 9 |
| 28052935 | 2017 | D120 and K152 within the PH Domain of T Cell Adapter SKAP55 Regulate Plasma Membrane Targeting of SKAP55 and LFA-1 Affinity Modulation in Human T Lymphocytes. | 9 |
| 24368808 | 2013 | The N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms. | 17 |
| 24368808 | 2013 | The N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms. | 17 |
| 21652578 | 2012 | Genetic polymorphisms in androgen receptor-binding sites predict survival in prostate cancer patients receiving androgen-deprivation therapy. | 29 |
| 21652578 | 2012 | Genetic polymorphisms in androgen receptor-binding sites predict survival in prostate cancer patients receiving androgen-deprivation therapy. | 29 |
| 21669874 | 2011 | SKAP1 protein PH domain determines RapL membrane localization and Rap1 protein complex formation for T cell receptor (TCR) activation of LFA-1. | 29 |
Citation
Dessen P
SKAP1 (src kinase associated phosphoprotein 1)
Atlas Genet Cytogenet Oncol Haematol. 2010-11-01
Online version: http://atlasgeneticsoncology.org/gene/51757/skap1-(src-kinase-associated-phosphoprotein-1)
