HTN3 (histatin 3)

2010-11-01 Affiliation

Identity

HGNC

HTN3

LOCATION

4q13.3

LOCUSID

3347

ALIAS

HIS2,HTN2,HTN5,PB

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3347
MIM: 142702
HGNC: 5284
Ensembl: ENSG00000205649

Variants:

dbSNP: 3347
ClinVar: 3347
TCGA: ENSG00000205649
COSMIC: HTN3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000205649	ENST00000381057	X6RAH8
ENSG00000205649	ENST00000526767	P15516
ENSG00000205649	ENST00000530128	P15516

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Salivary secretion	KEGG	ko04970
Salivary secretion	KEGG	hsa04970
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Antimicrobial peptides	REACTOME	R-HSA-6803157

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36826226	2023	Salivary Antimicrobial Peptide Histatin-5 Does Not Display Zn(II)-Dependent or -Independent Activity against Streptococci.	1
36826226	2023	Salivary Antimicrobial Peptide Histatin-5 Does Not Display Zn(II)-Dependent or -Independent Activity against Streptococci.	1
35489730	2022	Association Between PD-L1 and Histatin1, 3 Expression in Advanced Head and Neck Squamous Cell Carcinoma.	0
35489730	2022	Association Between PD-L1 and Histatin1, 3 Expression in Advanced Head and Neck Squamous Cell Carcinoma.	0
33596477	2021	Histatin 5 variant reduces Candida albicans biofilm viability and inhibits biofilm formation.	6
33596477	2021	Histatin 5 variant reduces Candida albicans biofilm viability and inhibits biofilm formation.	6
32225006	2020	Salivary Histatin 1 and 2 Are Targeted to Mitochondria and Endoplasmic Reticulum in Human Cells.	7
32225006	2020	Salivary Histatin 1 and 2 Are Targeted to Mitochondria and Endoplasmic Reticulum in Human Cells.	7
30520817	2019	The HTN3-MSANTD3 Fusion Gene Defines a Subset of Acinic Cell Carcinoma of the Salivary Gland.	17
30520817	2019	The HTN3-MSANTD3 Fusion Gene Defines a Subset of Acinic Cell Carcinoma of the Salivary Gland.	17
29217144	2018	Histatin-5 induces the reversal of Pdr5p mediated fluconazole resistance in Saccharomyces cerevisae.	1
29446150	2018	Antimicrobial peptide gene expression in periodontitis patients: A pilot study.	6
29217144	2018	Histatin-5 induces the reversal of Pdr5p mediated fluconazole resistance in Saccharomyces cerevisae.	1
29446150	2018	Antimicrobial peptide gene expression in periodontitis patients: A pilot study.	6
28627688	2017	Danger-recognizing proteins, β-defensin-128 and histatin-3, as potential biomarkers of recurrent coronary events.	2

Citation

Dessen P

HTN3 (histatin 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-11-01

Online version: http://atlasgeneticsoncology.org/gene/51767/htn3-(histatin-3)