DROSHA (drosha ribonuclease III)

2010-11-01  

Identity

HGNC
DROSHA
LOCATION
5p13.3
LOCUSID
29102
ALIAS
ETOHI2,HSA242976,RANSE3L,RN3,RNASE3L,RNASEN
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 29102
MIM: 608828
HGNC: 17904
Ensembl: ENSG00000113360

Variants:

dbSNP: 29102
ClinVar: 29102
TCGA: ENSG00000113360
COSMIC: DROSHA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113360ENST00000344624Q9NRR4
ENSG00000113360ENST00000442743Q9NRR4
ENSG00000113360ENST00000507438E5RHD1
ENSG00000113360ENST00000511367Q9NRR4
ENSG00000113360ENST00000512076H7C5U6
ENSG00000113360ENST00000512302H0YB67
ENSG00000113360ENST00000513349Q9NRR4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ribosome biogenesis in eukaryotesKEGGko03008
Ribosome biogenesis in eukaryotesKEGGhsa03008
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Gene ExpressionREACTOMER-HSA-74160
Gene Silencing by RNAREACTOMER-HSA-211000
MicroRNA (miRNA) biogenesisREACTOMER-HSA-203927

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA446155Precursor Cell Lymphoblastic Leukemia-LymphomaDiseaseClinicalAnnotationassociatedPD24614921
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD24614921
PA449177cytarabineChemicalClinicalAnnotationassociatedPD24614921
PA449212daunorubicinChemicalClinicalAnnotationassociatedPD24614921
PA450379mercaptopurineChemicalClinicalAnnotationassociatedPD24614921
PA450428methotrexateChemicalClinicalAnnotationassociatedPD24614921
PA451100prednisoneChemicalClinicalAnnotationassociatedPD24614921
PA451879vincristineChemicalClinicalAnnotationassociatedPD24614921

References

Pubmed IDYearTitleCitations
382418482024Cytoplasmic and nuclear DROSHA in human villous trophoblasts.0
382418482024Cytoplasmic and nuclear DROSHA in human villous trophoblasts.0
369119282023Association of DROSHA rs6877842, rs642321 and rs10719 polymorphisms with increased susceptibility to breast cancer: A case-control study with genotype and haplotype analysis.0
369830352023Downregulation of DROSHA: Could It Affect miRNA Biogenesis in Endometriotic Menstrual Blood Mesenchymal Stem Cells?1
370995692023The 3' UTR polymorphisms rs3742330 in DICER1 and rs10719 in DROSHA genes are not associated with primary open-angle and angle-closure glaucoma: As case-control study.0
369119282023Association of DROSHA rs6877842, rs642321 and rs10719 polymorphisms with increased susceptibility to breast cancer: A case-control study with genotype and haplotype analysis.0
369830352023Downregulation of DROSHA: Could It Affect miRNA Biogenesis in Endometriotic Menstrual Blood Mesenchymal Stem Cells?1
370995692023The 3' UTR polymorphisms rs3742330 in DICER1 and rs10719 in DROSHA genes are not associated with primary open-angle and angle-closure glaucoma: As case-control study.0
348551932022The impact of Dicer, Drosha, and Exportin-5 levels in polycystic ovary syndrome (PCOS) diagnosis and phenotyping.0
354050102022The microRNA processor DROSHA is a candidate gene for a severe progressive neurological disorder.1
362109812022The Drosha-Independent MicroRNA6778-5p/GSK3β Axis Mediates the Proliferation of Gastric Cancer Cells.0
365153512022Immunohistochemical expression of Drosha is reduced in eutopic and ectopic endometrium of women with adenomyosis.1
348551932022The impact of Dicer, Drosha, and Exportin-5 levels in polycystic ovary syndrome (PCOS) diagnosis and phenotyping.0
354050102022The microRNA processor DROSHA is a candidate gene for a severe progressive neurological disorder.1
362109812022The Drosha-Independent MicroRNA6778-5p/GSK3β Axis Mediates the Proliferation of Gastric Cancer Cells.0

Citation

Dessen P

DROSHA (drosha ribonuclease III)

Atlas Genet Cytogenet Oncol Haematol. 2010-11-01

Online version: http://atlasgeneticsoncology.org/gene/51768