Identity
HGNC
LOCATION
6p21.33
LOCUSID
ALIAS
AHUS4,ARMD14,BF,BFD,CFAB,CFBD,FB,FBI12,GBG,H2-Bf,PBF2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 629
MIM: 138470
HGNC: 1037
Ensembl: ENSG00000243649
Variants:
dbSNP: 629
ClinVar: 629
TCGA: ENSG00000243649
COSMIC: CFB
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36805858 | 2023 | Targeted genotyping of COVID-19 patients reveals a signature of complement C3 and factor B coding SNPs associated with severe infection. | 3 |
| 37080587 | 2023 | Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis. | 3 |
| 37098439 | 2023 | Defective microbial sensing and clearance in perianal Crohn's disease: a role for complement factor B. | 0 |
| 36805858 | 2023 | Targeted genotyping of COVID-19 patients reveals a signature of complement C3 and factor B coding SNPs associated with severe infection. | 3 |
| 37080587 | 2023 | Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis. | 3 |
| 37098439 | 2023 | Defective microbial sensing and clearance in perianal Crohn's disease: a role for complement factor B. | 0 |
| 34585312 | 2022 | Serum complement factor B is associated with disease activity and progression of idiopathic membranous nephropathy concomitant with IgA nephropathy. | 2 |
| 36311737 | 2022 | Functional variant rs12614 in CFB confers a low risk of IgA nephropathy by attenuating complement alternative pathway activation in Han Chinese. | 1 |
| 34585312 | 2022 | Serum complement factor B is associated with disease activity and progression of idiopathic membranous nephropathy concomitant with IgA nephropathy. | 2 |
| 36311737 | 2022 | Functional variant rs12614 in CFB confers a low risk of IgA nephropathy by attenuating complement alternative pathway activation in Han Chinese. | 1 |
| 33419768 | 2021 | Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B. | 5 |
| 33536243 | 2021 | Inherited Kidney Complement Diseases. | 14 |
| 33740660 | 2021 | Complement component factor B has thrombin-like activity. | 0 |
| 33847939 | 2021 | Detection of Complement Factor B Autoantibodies by ELISA. | 2 |
| 33847940 | 2021 | Detection of C3 Nephritic Factor by Hemolytic Assay. | 2 |
Citation
Dessen P
CFB (complement factor B)
Atlas Genet Cytogenet Oncol Haematol. 2010-11-01
Online version: http://atlasgeneticsoncology.org/gene/51771/cfb-(complement-factor-b)
