KCNK5 (potassium two pore domain channel subfamily K member 5)

2010-11-01  

Identity

HGNC
KCNK5
LOCATION
6p21.2
LOCUSID
8645
ALIAS
K2p5.1,KCNK5b,TASK-2,TASK2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8645
MIM: 603493
HGNC: 6280
Ensembl: ENSG00000164626

Variants:

dbSNP: 8645
ClinVar: 8645
TCGA: ENSG00000164626
COSMIC: KCNK5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164626ENST00000359534O95279
ENSG00000164626ENST00000359534A0A024RD32

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Taste transductionKEGGko04742
Taste transductionKEGGhsa04742
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974
Muscle contractionREACTOMER-HSA-397014
Cardiac conductionREACTOMER-HSA-5576891
Phase 4 - resting membrane potentialREACTOMER-HSA-5576886

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382361862024KCNK5 Regulating Potassium Efflux and Inducing Pyroptosis in Corneal Epithelial Cells Through TNFSF10-Mediated Autophagy in Dry Eye.0
382361862024KCNK5 Regulating Potassium Efflux and Inducing Pyroptosis in Corneal Epithelial Cells Through TNFSF10-Mediated Autophagy in Dry Eye.0
337626372021Common variants in KCNK5 and FHL5 genes contributed to the susceptibility of migraine without aura in Han Chinese population.4
337626372021Common variants in KCNK5 and FHL5 genes contributed to the susceptibility of migraine without aura in Han Chinese population.4
292939172018Mutations of the Twik-Related Acid-Sensitive K+ Channel 2 Promoter in Human Primary Aldosteronism.3
292939172018Mutations of the Twik-Related Acid-Sensitive K+ Channel 2 Promoter in Human Primary Aldosteronism.3
280459952017Analysis of Hypoxic and Hypercapnic Ventilatory Response in Healthy Volunteers.16
286043872017Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma.28
288652452017The SH2B3 and KCNK5 loci may be implicated in regulation of platelet count, volume, and maturity.2
280459952017Analysis of Hypoxic and Hypercapnic Ventilatory Response in Healthy Volunteers.16
286043872017Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma.28
288652452017The SH2B3 and KCNK5 loci may be implicated in regulation of platelet count, volume, and maturity.2
269097372016The Volume Activated Potassium Channel KCNK5 is Up-Regulated in Activated Human T Cells, but Volume Regulation is Impaired.3
272281682016Dominant-Negative Effect of a Missense Variant in the TASK-2 (KCNK5) K+ Channel Associated with Balkan Endemic Nephropathy.7
269097372016The Volume Activated Potassium Channel KCNK5 is Up-Regulated in Activated Human T Cells, but Volume Regulation is Impaired.3

Citation

Dessen P

KCNK5 (potassium two pore domain channel subfamily K member 5)

Atlas Genet Cytogenet Oncol Haematol. 2010-11-01

Online version: http://atlasgeneticsoncology.org/gene/51772/kcnk5-(potassium-two-pore-domain-channel-subfamily-k-member-5)