NFIC (nuclear factor I C)

2010-12-01  

Identity

HGNC
NFIC
LOCATION
19p13.3
LOCUSID
4782
ALIAS
CTF,CTF5,NF-I,NFI
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4782
MIM: 600729
HGNC: 7786
Ensembl: ENSG00000141905

Variants:

dbSNP: 4782
ClinVar: 4782
TCGA: ENSG00000141905
COSMIC: NFIC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141905ENST00000341919P08651
ENSG00000141905ENST00000395111P08651
ENSG00000141905ENST00000443272P08651
ENSG00000141905ENST00000586919P08651
ENSG00000141905ENST00000589123P08651
ENSG00000141905ENST00000590282P08651
ENSG00000141905ENST00000641145A0A286YEX4

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase III TranscriptionREACTOMER-HSA-74158
RNA Polymerase III Abortive And Retractive InitiationREACTOMER-HSA-749476
RNA Polymerase III Transcription TerminationREACTOMER-HSA-73980

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382677312024Activation of CHPF by transcription factor NFIC promotes NLRP3 activation during the progression of colorectal cancer.0
385285262024rs822336 binding to C/EBPβ and NFIC modulates induction of PD-L1 expression and predicts anti-PD-1/PD-L1 therapy in advanced NSCLC.2
382677312024Activation of CHPF by transcription factor NFIC promotes NLRP3 activation during the progression of colorectal cancer.0
385285262024rs822336 binding to C/EBPβ and NFIC modulates induction of PD-L1 expression and predicts anti-PD-1/PD-L1 therapy in advanced NSCLC.2
365727502023Nuclear factor I-C overexpression promotes monocytic development and cell survival in acute myeloid leukemia.2
365749142023NFIC1 inhibits the migration and invasion of MDA-MB-231 cells through S100A2-mediated inactivation of MEK/ERK pathway.0
373534852023NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation.2
377102992023Adipose-derived stem cell exosome NFIC improves diabetic foot ulcers by regulating miR-204-3p/HIPK2.4
365727502023Nuclear factor I-C overexpression promotes monocytic development and cell survival in acute myeloid leukemia.2
365749142023NFIC1 inhibits the migration and invasion of MDA-MB-231 cells through S100A2-mediated inactivation of MEK/ERK pathway.0
373534852023NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation.2
377102992023Adipose-derived stem cell exosome NFIC improves diabetic foot ulcers by regulating miR-204-3p/HIPK2.4
348074712022Hsa-miRNA-143-3p regulates the odontogenic differentiation of human stem cells from the apical papilla by targeting NFIC.3
349853872022Transcription factor NFIC functions as a tumor suppressor in lung squamous cell carcinoma progression by modulating lncRNA CASC2.5
352930502022Insulin-like growth factor 2 mRNA-binding protein 2-regulated alternative splicing of nuclear factor 1 C-type causes excessive granulosa cell proliferation in polycystic ovary syndrome.5

Citation

Dessen P

NFIC (nuclear factor I C)

Atlas Genet Cytogenet Oncol Haematol. 2010-12-01

Online version: http://atlasgeneticsoncology.org/gene/51783/nfic-(nuclear-factor-i-c)