Identity
HGNC
LOCATION
8q24.12
LOCUSID
ALIAS
DEP.6,DEPDC6
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 64798
MIM: 612974
HGNC: 22953
Ensembl: ENSG00000155792
Variants:
dbSNP: 64798
ClinVar: 64798
TCGA: ENSG00000155792
COSMIC: DEPTOR
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000155792 | ENST00000286234 | Q8TB45 |
| ENSG00000155792 | ENST00000523492 | Q8TB45 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Autophagy - animal | KEGG | ko04140 |
| mTOR signaling pathway | KEGG | ko04150 |
| Autophagy - animal | KEGG | hsa04140 |
| mTOR signaling pathway | KEGG | hsa04150 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36548081 | 2023 | The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor suppressor cascade in lung cancer cells. | 12 |
| 37054772 | 2023 | DEPTOR as a novel prognostic marker inhibits the proliferation via deactivating mTOR signaling pathway in gastric cancer cells. | 2 |
| 37469018 | 2023 | PUM1 Promotes Tumor Progression by Activating DEPTOR-Meditated Glycolysis in Gastric Cancer. | 3 |
| 36548081 | 2023 | The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor suppressor cascade in lung cancer cells. | 12 |
| 37054772 | 2023 | DEPTOR as a novel prognostic marker inhibits the proliferation via deactivating mTOR signaling pathway in gastric cancer cells. | 2 |
| 37469018 | 2023 | PUM1 Promotes Tumor Progression by Activating DEPTOR-Meditated Glycolysis in Gastric Cancer. | 3 |
| 35216969 | 2022 | Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation. | 2 |
| 35923131 | 2022 | DFNA5 inhibits colorectal cancer proliferation by suppressing the mTORC1/2 signaling pathways via upregulation of DEPTOR. | 1 |
| 35216969 | 2022 | Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation. | 2 |
| 35923131 | 2022 | DFNA5 inhibits colorectal cancer proliferation by suppressing the mTORC1/2 signaling pathways via upregulation of DEPTOR. | 1 |
| 33110214 | 2021 | Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathways. | 15 |
| 33412518 | 2021 | Function of Deptor and its roles in hematological malignancies. | 3 |
| 33416146 | 2021 | Regulatory role of DEPTOR‑mediated cellular autophagy and mitochondrial reactive oxygen species in angiogenesis in multiple myeloma. | 2 |
| 33854045 | 2021 | Nuclear ErbB2 represses DEPTOR transcription to inhibit autophagy in breast cancer cells. | 4 |
| 33865870 | 2021 | Structural Basis of DEPTOR to Recognize Phosphatidic Acid Using its Tandem DEP Domains. | 4 |
Citation
Dessen P
DEPTOR (DEP domain containing MTOR interacting protein)
Atlas Genet Cytogenet Oncol Haematol. 2010-12-01
Online version: http://atlasgeneticsoncology.org/gene/51800/deptor-(dep-domain-containing-mtor-interacting-protein)
