MZB1 (marginal zone B and B1 cell specific protein)

2010-12-01  

Identity

HGNC
MZB1
LOCATION
5q31.2
LOCUSID
51237
ALIAS
MEDA-7,PACAP,pERp1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51237
MIM: 609447
HGNC: 30125
Ensembl: ENSG00000170476

Variants:

dbSNP: 51237
ClinVar: 51237
TCGA: ENSG00000170476
COSMIC: MZB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170476ENST00000302125Q8WU39
ENSG00000170476ENST00000417694Q8WU39
ENSG00000170476ENST00000503351H0Y9L3
ENSG00000170476ENST00000503481Q8WU39
ENSG00000170476ENST00000513389D6RII0

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
thymus
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378526032024MZB1-expressing cells are essential for local immunoglobulin production in chronic rhinosinusitis with nasal polyps.0
385083492024MZB1 regulates cellular proliferation, mitochondrial dysfunction, and inflammation and targets the PI3K-Akt signaling pathway in acute pancreatitis.0
378526032024MZB1-expressing cells are essential for local immunoglobulin production in chronic rhinosinusitis with nasal polyps.0
385083492024MZB1 regulates cellular proliferation, mitochondrial dysfunction, and inflammation and targets the PI3K-Akt signaling pathway in acute pancreatitis.0
373322602023Altered expression of MZB1 in periodontitis: A possible link to disease pathogenesis.1
373322602023Altered expression of MZB1 in periodontitis: A possible link to disease pathogenesis.1
356534942022MZB1 targeted by miR-185-5p inhibits the migration of human periodontal ligament cells through NF-κB signaling and promotes alveolar bone loss.3
356534942022MZB1 targeted by miR-185-5p inhibits the migration of human periodontal ligament cells through NF-κB signaling and promotes alveolar bone loss.3
334531882021High-resolution Crystal Structure of Human pERp1, A Saposin-like Protein Involved in IgA, IgM and Integrin Maturation in the Endoplasmic Reticulum.6
334531882021High-resolution Crystal Structure of Human pERp1, A Saposin-like Protein Involved in IgA, IgM and Integrin Maturation in the Endoplasmic Reticulum.6
319017572020COL1A1 and MZB1 as the hub genes influenced the proliferation, invasion, migration and apoptosis of rectum adenocarcinoma cells by weighted correlation network analysis.12
323777232020Proteomics and functional study reveal marginal zone B and B1 cell specific protein as a candidate marker of multiple myeloma.6
319017572020COL1A1 and MZB1 as the hub genes influenced the proliferation, invasion, migration and apoptosis of rectum adenocarcinoma cells by weighted correlation network analysis.12
323777232020Proteomics and functional study reveal marginal zone B and B1 cell specific protein as a candidate marker of multiple myeloma.6
293823652018Increase of MZB1 in B cells in systemic lupus erythematosus: proteomic analysis of biopsied lymph nodes.19

Citation

Dessen P

MZB1 (marginal zone B and B1 cell specific protein)

Atlas Genet Cytogenet Oncol Haematol. 2010-12-01

Online version: http://atlasgeneticsoncology.org/gene/51804/mzb1-(marginal-zone-b-and-b1-cell-specific-protein)