PREP (prolyl endopeptidase)

2011-02-01  

Identity

HGNC
LOCATION
6q21
LOCUSID
ALIAS
PE,PEP
FUSION GENES

Other Information

Locus ID:

NCBI: 5550
MIM: 600400
HGNC: 9358
Ensembl: ENSG00000085377

Variants:

dbSNP: 5550
ClinVar: 5550
TCGA: ENSG00000085377
COSMIC: PREP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000085377ENST00000369110A0A499FJL1
ENSG00000085377ENST00000448705H0Y5Y0
ENSG00000085377ENST00000652536P48147

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Renin-angiotensin systemKEGGko04614
Renin-angiotensin systemKEGGhsa04614

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
204680642010Association study of 182 candidate genes in anorexia nervosa.30
160929402005Subcellular localization suggests novel functions for prolyl endopeptidase in protein secretion.21
227403432012Distribution of prolyl oligopeptidase in human peripheral tissues and in ovarian and colorectal tumors.15
262221442016Toll-Like Receptor 4 Engagement Mediates Prolyl Endopeptidase Release from Airway Epithelia via Exosomes.15
174016472007Distribution of immunoreactive prolyl oligopeptidase in human and rat brain.12
221320712011Structural analysis of prolyl oligopeptidases using molecular docking and dynamics: insights into conformational changes and ligand binding.11
203626292010Increased prolyl endopeptidase activity in human neoplasia.10
214872122011Prolyl endopeptidase is involved in cellular signalling in human neuroblastoma SH-SY5Y cells.10
249314692014Molecular basis of substrate recognition and degradation by human presequence protease.10

Citation

Dessen P

PREP (prolyl endopeptidase)

Atlas Genet Cytogenet Oncol Haematol. 2011-02-01

Online version: http://atlasgeneticsoncology.org/gene/52044/prep-(prolyl-endopeptidase)