Identity
HGNC
LOCATION
7q36.2
LOCUSID
ALIAS
CAGF28,CAGF29,PACIP1,PAXIP1L,PTIP,TNRC2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 22976
MIM: 608254
HGNC: 8624
Ensembl: ENSG00000157212
Variants:
dbSNP: 22976
ClinVar: 22976
TCGA: ENSG00000157212
COSMIC: PAXIP1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000157212 | ENST00000397192 | Q6ZW49 |
| ENSG00000157212 | ENST00000404141 | Q6ZW49 |
| ENSG00000157212 | ENST00000419436 | H7BZI8 |
| ENSG00000157212 | ENST00000457196 | F8WC23 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38244928 | 2024 | Longitudinal profiling identifies co-occurring BRCA1/2 reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor-resistant advanced breast cancer. | 4 |
| 38244928 | 2024 | Longitudinal profiling identifies co-occurring BRCA1/2 reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor-resistant advanced breast cancer. | 4 |
| 35354042 | 2022 | PTIP governs NAD(+) metabolism by regulating CD38 expression to drive macrophage inflammation. | 3 |
| 35768906 | 2022 | Polymorphisms in the HSF2, LRRC6, MEIG1 and PTIP genes correlate with sperm motility in idiopathic infertility. | 1 |
| 35354042 | 2022 | PTIP governs NAD(+) metabolism by regulating CD38 expression to drive macrophage inflammation. | 3 |
| 35768906 | 2022 | Polymorphisms in the HSF2, LRRC6, MEIG1 and PTIP genes correlate with sperm motility in idiopathic infertility. | 1 |
| 28475402 | 2017 | DNA repair genes PAXIP1 and TP53BP1 expression is associated with breast cancer prognosis. | 13 |
| 28475402 | 2017 | DNA repair genes PAXIP1 and TP53BP1 expression is associated with breast cancer prognosis. | 13 |
| 27196765 | 2016 | PAXIP1 Potentiates the Combination of WEE1 Inhibitor AZD1775 and Platinum Agents in Lung Cancer. | 15 |
| 27196765 | 2016 | PAXIP1 Potentiates the Combination of WEE1 Inhibitor AZD1775 and Platinum Agents in Lung Cancer. | 15 |
| 25631048 | 2015 | The Groucho-associated phosphatase PPM1B displaces Pax transactivation domain interacting protein (PTIP) to switch the transcription factor Pax2 from a transcriptional activator to a repressor. | 15 |
| 25631048 | 2015 | The Groucho-associated phosphatase PPM1B displaces Pax transactivation domain interacting protein (PTIP) to switch the transcription factor Pax2 from a transcriptional activator to a repressor. | 15 |
| 24486544 | 2014 | PITX2 associates with PTIP-containing histone H3 lysine 4 methyltransferase complex. | 5 |
| 25512557 | 2014 | PTIP associates with Artemis to dictate DNA repair pathway choice. | 73 |
| 24486544 | 2014 | PITX2 associates with PTIP-containing histone H3 lysine 4 methyltransferase complex. | 5 |
Citation
Dessen P
PAXIP1 (PAX interacting protein 1)
Atlas Genet Cytogenet Oncol Haematol. 2011-02-01
Online version: http://atlasgeneticsoncology.org/gene/52076/paxip1-(pax-interacting-protein-1)
