Identity
HGNC
LOCATION
3q25.1
LOCUSID
ALIAS
CDA02,EIF-2A,MST089,MSTP004,MSTP089
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 83939
MIM: 609234
HGNC: 3254
Ensembl: ENSG00000144895
Variants:
dbSNP: 83939
ClinVar: 83939
TCGA: ENSG00000144895
COSMIC: EIF2A
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38433101 | 2024 | To initiate or not to initiate: A critical assessment of eIF2A, eIF2D, and MCT-1·DENR to deliver initiator tRNA to ribosomes. | 0 |
| 38433101 | 2024 | To initiate or not to initiate: A critical assessment of eIF2A, eIF2D, and MCT-1·DENR to deliver initiator tRNA to ribosomes. | 0 |
| 36689548 | 2023 | The enterovirus genome can be translated in an IRES-independent manner that requires the initiation factors eIF2A/eIF2D. | 6 |
| 37581984 | 2023 | Genome-wide CRISPR screens identify noncanonical translation factor eIF2A as an enhancer of SARS-CoV-2 programmed -1 ribosomal frameshifting. | 1 |
| 37602404 | 2023 | Increased levels of eIF2A inhibit translation by sequestering 40S ribosomal subunits. | 3 |
| 36689548 | 2023 | The enterovirus genome can be translated in an IRES-independent manner that requires the initiation factors eIF2A/eIF2D. | 6 |
| 37581984 | 2023 | Genome-wide CRISPR screens identify noncanonical translation factor eIF2A as an enhancer of SARS-CoV-2 programmed -1 ribosomal frameshifting. | 1 |
| 37602404 | 2023 | Increased levels of eIF2A inhibit translation by sequestering 40S ribosomal subunits. | 3 |
| 36555509 | 2022 | PKR-Mediated Phosphorylation of eIF2a and CHK1 Is Associated with Doxorubicin-Mediated Apoptosis in HCC1143 Triple-Negative Breast Cancer Cells. | 1 |
| 36555509 | 2022 | PKR-Mediated Phosphorylation of eIF2a and CHK1 Is Associated with Doxorubicin-Mediated Apoptosis in HCC1143 Triple-Negative Breast Cancer Cells. | 1 |
| 32892501 | 2021 | The eIF2α kinase HRI in innate immunity, proteostasis, and mitochondrial stress. | 19 |
| 33705388 | 2021 | MARK2 phosphorylates eIF2α in response to proteotoxic stress. | 16 |
| 33837631 | 2021 | CCCP-induced mitochondrial dysfunction - characterization and analysis of integrated stress response to cellular signaling and homeostasis. | 17 |
| 33856033 | 2021 | The alternative initiation factor eIF2A plays key role in RAN translation of myotonic dystrophy type 2 CCUG•CAGG repeats. | 11 |
| 34663797 | 2021 | Downregulation of PHLPP induced by endoplasmic reticulum stress promotes eIF2α phosphorylation and chemoresistance in colon cancer. | 7 |
Citation
Dessen P
EIF2A (eukaryotic translation initiation factor 2A)
Atlas Genet Cytogenet Oncol Haematol. 2011-02-01
Online version: http://atlasgeneticsoncology.org/gene/52079/eif2a-(eukaryotic-translation-initiation-factor-2a)
