EIF2A (eukaryotic translation initiation factor 2A)

2011-02-01  

Identity

HGNC
EIF2A
LOCATION
3q25.1
LOCUSID
83939
ALIAS
CDA02,EIF-2A,MST089,MSTP004,MSTP089
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 83939
MIM: 609234
HGNC: 3254
Ensembl: ENSG00000144895

Variants:

dbSNP: 83939
ClinVar: 83939
TCGA: ENSG00000144895
COSMIC: EIF2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144895ENST00000273435F8WAE5
ENSG00000144895ENST00000406576Q9BY44
ENSG00000144895ENST00000460851Q9BY44
ENSG00000144895ENST00000462221H7C5Q4
ENSG00000144895ENST00000465535H7C5R5
ENSG00000144895ENST00000477551H7C5Q3
ENSG00000144895ENST00000482093C9IZE1
ENSG00000144895ENST00000487799Q9BY44
ENSG00000144895ENST00000490505F8WAT3
ENSG00000144895ENST00000494558F8WF18

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384331012024To initiate or not to initiate: A critical assessment of eIF2A, eIF2D, and MCT-1·DENR to deliver initiator tRNA to ribosomes.0
384331012024To initiate or not to initiate: A critical assessment of eIF2A, eIF2D, and MCT-1·DENR to deliver initiator tRNA to ribosomes.0
366895482023The enterovirus genome can be translated in an IRES-independent manner that requires the initiation factors eIF2A/eIF2D.6
375819842023Genome-wide CRISPR screens identify noncanonical translation factor eIF2A as an enhancer of SARS-CoV-2 programmed -1 ribosomal frameshifting.1
376024042023Increased levels of eIF2A inhibit translation by sequestering 40S ribosomal subunits.3
366895482023The enterovirus genome can be translated in an IRES-independent manner that requires the initiation factors eIF2A/eIF2D.6
375819842023Genome-wide CRISPR screens identify noncanonical translation factor eIF2A as an enhancer of SARS-CoV-2 programmed -1 ribosomal frameshifting.1
376024042023Increased levels of eIF2A inhibit translation by sequestering 40S ribosomal subunits.3
365555092022PKR-Mediated Phosphorylation of eIF2a and CHK1 Is Associated with Doxorubicin-Mediated Apoptosis in HCC1143 Triple-Negative Breast Cancer Cells.1
365555092022PKR-Mediated Phosphorylation of eIF2a and CHK1 Is Associated with Doxorubicin-Mediated Apoptosis in HCC1143 Triple-Negative Breast Cancer Cells.1
328925012021The eIF2α kinase HRI in innate immunity, proteostasis, and mitochondrial stress.19
337053882021MARK2 phosphorylates eIF2α in response to proteotoxic stress.16
338376312021CCCP-induced mitochondrial dysfunction - characterization and analysis of integrated stress response to cellular signaling and homeostasis.17
338560332021The alternative initiation factor eIF2A plays key role in RAN translation of myotonic dystrophy type 2 CCUG•CAGG repeats.11
346637972021Downregulation of PHLPP induced by endoplasmic reticulum stress promotes eIF2α phosphorylation and chemoresistance in colon cancer.7

Citation

Dessen P

EIF2A (eukaryotic translation initiation factor 2A)

Atlas Genet Cytogenet Oncol Haematol. 2011-02-01

Online version: http://atlasgeneticsoncology.org/gene/52079/eif2a-(eukaryotic-translation-initiation-factor-2a)