STAP2 (signal transducing adaptor family member 2)

2011-02-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
BKS
FUSION GENES

Other Information

Locus ID:

NCBI: 55620
MIM: 607881
HGNC: 30430
Ensembl: ENSG00000178078

Variants:

dbSNP: 55620
ClinVar: 55620
TCGA: ENSG00000178078
COSMIC: STAP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178078ENST00000594605Q9UGK3
ENSG00000178078ENST00000598443M0R0J5
ENSG00000178078ENST00000599736M0QZ60
ENSG00000178078ENST00000600324Q9UGK3
ENSG00000178078ENST00000601482M0R2W4
ENSG00000178078ENST00000601956M0QY82

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by PTK6REACTOMER-HSA-8848021
PTK6 Activates STAT3REACTOMER-HSA-8849474

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
193936272009STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation.19
206770142010An approach based on a genome-wide association study reveals candidate loci for narcolepsy.16
209298632010Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells.15
176755012007Signal-transducing adaptor protein-2 regulates integrin-mediated T cell adhesion through protein degradation of focal adhesion kinase.12
185738902008STAP-2 negatively regulates both canonical and noncanonical NF-kappaB activation induced by Epstein-Barr virus-derived latent membrane protein 1.8
199338632009Signal-transducing adaptor protein-2 regulates stromal cell-derived factor-1 alpha-induced chemotaxis in T cells.7
156110912005Physical and functional interactions between STAP-2/BKS and STAT5.5
237000422013Estrogen-related genome-based expression profiling study of uterosacral ligaments in women with pelvic organ prolapse.3
222314452012STAP-2 interacts with and modulates BCR-ABL-mediated tumorigenesis.2
226112432012Signal-transducing adaptor protein-2 modulates Fas-mediated T cell apoptosis by interacting with caspase-8.2

Citation

Dessen P

STAP2 (signal transducing adaptor family member 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-02-01

Online version: http://atlasgeneticsoncology.org/gene/52081/stap2-(signal-transducing-adaptor-family-member-2)