P2RX4 (purinergic receptor P2X 4)

2011-02-01  

Identity

HGNC
LOCATION
12q24.31
LOCUSID
ALIAS
P2X4,P2X4R
FUSION GENES

Other Information

Locus ID:

NCBI: 5025
MIM: 600846
HGNC: 8535
Ensembl: ENSG00000135124

Variants:

dbSNP: 5025
ClinVar: 5025
TCGA: ENSG00000135124
COSMIC: P2RX4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135124ENST00000337233Q99571
ENSG00000135124ENST00000359949Q99571
ENSG00000135124ENST00000538417H0YF70
ENSG00000135124ENST00000538701F5H1M6
ENSG00000135124ENST00000542067Q99571
ENSG00000135124ENST00000543171F6SFZ6
ENSG00000135124ENST00000543318F5GZQ9
ENSG00000135124ENST00000543984F5H2S3

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Platelet calcium homeostasisREACTOMER-HSA-418360
Elevation of cytosolic Ca2+ levelsREACTOMER-HSA-139853

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
206602882010Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse.113
228370362012P2X4R+ microglia drive neuropathic pain.96
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
234345412013ATP-P2X4 signaling mediates NLRP3 inflammasome activation: a novel pathway of diabetic nephropathy.64
239361652013P2X4 assembles with P2X7 and pannexin-1 in gingival epithelial cells and modulates ATP-induced reactive oxygen species production and inflammasome activation.55
218080182011Preferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors).40
248171232014P2X4 forms functional ATP-activated cation channels on lysosomal membranes regulated by luminal pH.40
165338082006A C-terminal lysine that controls human P2X4 receptor desensitization.39
127143212003Endogenously released ATP mediates shear stress-induced Ca2+ influx into pulmonary artery endothelial cells.36
261012202015Calcium release through P2X4 activates calmodulin to promote endolysosomal membrane fusion.36

Citation

Dessen P

P2RX4 (purinergic receptor P2X 4)

Atlas Genet Cytogenet Oncol Haematol. 2011-02-01

Online version: http://atlasgeneticsoncology.org/gene/52083/p2rx4-(purinergic-receptor-p2x-4)