DPP8 (dipeptidyl peptidase 8)

2011-02-01  

Identity

HGNC
DPP8
LOCATION
15q22.31
LOCUSID
54878
ALIAS
DP8,DPRP-1,DPRP1,MST097,MSTP097,MSTP135,MSTP141
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54878
MIM: 606819
HGNC: 16490
Ensembl: ENSG00000074603

Variants:

dbSNP: 54878
ClinVar: 54878
TCGA: ENSG00000074603
COSMIC: DPP8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000074603ENST00000300141Q6V1X1
ENSG00000074603ENST00000321147Q6V1X1
ENSG00000074603ENST00000341861Q6V1X1
ENSG00000074603ENST00000341861A0A024R5Z6
ENSG00000074603ENST00000358939Q6V1X1
ENSG00000074603ENST00000395652J3KPT0
ENSG00000074603ENST00000558529H0YKA2
ENSG00000074603ENST00000558559H0YK36
ENSG00000074603ENST00000558786H3BNM2
ENSG00000074603ENST00000559233Q6V1X1
ENSG00000074603ENST00000559233A0A024R5Z6
ENSG00000074603ENST00000559526H3BQ40
ENSG00000074603ENST00000560436H0YN53
ENSG00000074603ENST00000560665H0YMV1

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384583392024DPP8/9 inhibition attenuates the TGF-β1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathways.0
384583392024DPP8/9 inhibition attenuates the TGF-β1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathways.0
339326092021Profibrotic mechanisms of DPP8 and DPP9 highly expressed in the proximal renal tubule epithelial cells.6
339326092021Profibrotic mechanisms of DPP8 and DPP9 highly expressed in the proximal renal tubule epithelial cells.6
329980732020Decrease of the pro-inflammatory M1-like response by inhibition of dipeptidyl peptidases 8/9 in THP-1 macrophages - quantitative proteomics of the proteome and secretome.3
329980732020Decrease of the pro-inflammatory M1-like response by inhibition of dipeptidyl peptidases 8/9 in THP-1 macrophages - quantitative proteomics of the proteome and secretome.3
302259512018Targeting dipeptidyl peptidase 8 genes inhibits proliferation, migration and invasion by inhibition of cyclin D1 and MMP2MMP9 signal pathway in cervical cancer.5
302259512018Targeting dipeptidyl peptidase 8 genes inhibits proliferation, migration and invasion by inhibition of cyclin D1 and MMP2MMP9 signal pathway in cervical cancer.5
254640202015Establishment of a dipeptidyl peptidases (DPP) 8/9 expressing cell model for evaluating the selectivity of DPP4 inhibitors.8
254640202015Establishment of a dipeptidyl peptidases (DPP) 8/9 expressing cell model for evaluating the selectivity of DPP4 inhibitors.8
235194732013Identifying natural substrates for dipeptidyl peptidases 8 and 9 using terminal amine isotopic labeling of substrates (TAILS) reveals in vivo roles in cellular homeostasis and energy metabolism.27
236087732013Dipeptidyl peptidases in atherosclerosis: expression and role in macrophage differentiation, activation and apoptosis.36
237048212013Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver.14
240727112013The SUMO1-E67 interacting loop peptide is an allosteric inhibitor of the dipeptidyl peptidases 8 and 9.7
235194732013Identifying natural substrates for dipeptidyl peptidases 8 and 9 using terminal amine isotopic labeling of substrates (TAILS) reveals in vivo roles in cellular homeostasis and energy metabolism.27

Citation

Dessen P

DPP8 (dipeptidyl peptidase 8)

Atlas Genet Cytogenet Oncol Haematol. 2011-02-01

Online version: http://atlasgeneticsoncology.org/gene/52087/dpp8-(dipeptidyl-peptidase-8)