DDX39A (DExD-box helicase 39A)

2011-02-01  

Identity

HGNC
LOCATION
19p13.12
LOCUSID
ALIAS
BAT1,BAT1L,DDX39,DDXL,URH49
FUSION GENES

Other Information

Locus ID:

NCBI: 10212
HGNC: 17821
Ensembl: ENSG00000123136

Variants:

dbSNP: 10212
ClinVar: 10212
TCGA: ENSG00000123136
COSMIC: DDX39A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123136ENST00000242776O00148
ENSG00000123136ENST00000324340O00148
ENSG00000123136ENST00000454233O00148
ENSG00000123136ENST00000586993K7EIL8
ENSG00000123136ENST00000588692O00148
ENSG00000123136ENST00000589675K7EQN7
ENSG00000123136ENST00000590239K7EN69
ENSG00000123136ENST00000590315K7EPJ3
ENSG00000123136ENST00000590696K7ENP6
ENSG00000123136ENST00000591275K7EL56
ENSG00000123136ENST00000592927A0A0D9SEM9

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA 3'-end processingREACTOMER-HSA-72187
Transport of Mature Transcript to CytoplasmREACTOMER-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing TranscriptREACTOMER-HSA-159236

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
205739852010The closely related RNA helicases, UAP56 and URH49, preferentially form distinct mRNA export machineries and coordinately regulate mitotic progression.37
169492172006Nuclear localization of poly(A)+ mRNA following siRNA reduction of expression of the mammalian RNA helicases UAP56 and URH49.34
150478532004Growth-regulated expression and G0-specific turnover of the mRNA that encodes URH49, a mammalian DExH/D box protein that is highly related to the mRNA export protein UAP56.25
171969632007Intracellular characterization of DDX39, a novel growth-associated RNA helicase.23
213884922011Requirement of DDX39 DEAD box RNA helicase for genome integrity and telomere protection.16
218597142011Interferon-induced antiviral protein MxA interacts with the cellular RNA helicases UAP56 and URH49.15
175489652007DDX39, upregulated in lung squamous cell cancer, displays RNA helicase activities and promotes cancer cell growth.13
221195462012Clinical proteomics identified ATP-dependent RNA helicase DDX39 as a novel biomarker to predict poor prognosis of patients with gastrointestinal stromal tumor.9
224940142012DDX39 acts as a suppressor of invasion for bladder cancer.9
280251392017The RNA helicase DDX39B and its paralog DDX39A regulate androgen receptor splice variant AR-V7 generation.9

Citation

Dessen P

DDX39A (DExD-box helicase 39A)

Atlas Genet Cytogenet Oncol Haematol. 2011-02-01

Online version: http://atlasgeneticsoncology.org/gene/52088/ddx39a-(dexd-box-helicase-39a)