FFAR2 (free fatty acid receptor 2)

2011-02-01  

Identity

HGNC
FFAR2
LOCATION
19q13.12
LOCUSID
2867
ALIAS
FFA2R,GPR43

Other Information

Locus ID:

NCBI: 2867
MIM: 603823
HGNC: 4501
Ensembl: ENSG00000126262

Variants:

dbSNP: 2867
ClinVar: 2867
TCGA: ENSG00000126262
COSMIC: FFAR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126262ENST00000246549O15552
ENSG00000126262ENST00000246549C6KYL4
ENSG00000126262ENST00000599180O15552
ENSG00000126262ENST00000599180C6KYL4

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Free fatty acid receptorsREACTOMER-HSA-444209
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382247772024Short chain fatty acids inhibit corneal inflammatory responses to TLR ligands via the ocular G-protein coupled receptor 43.0
386226722024Disordered GPR43/NLRP3 expression in peripheral leukocytes of patients with atrial fibrillation is associated with intestinal short chain fatty acids levels.0
387882492024Expression of free fatty acid receptor 2 in normal and neoplastic tissues.0
382247772024Short chain fatty acids inhibit corneal inflammatory responses to TLR ligands via the ocular G-protein coupled receptor 43.0
386226722024Disordered GPR43/NLRP3 expression in peripheral leukocytes of patients with atrial fibrillation is associated with intestinal short chain fatty acids levels.0
387882492024Expression of free fatty acid receptor 2 in normal and neoplastic tissues.0
357311422023Upregulated expression of FFAR2 and SOC3 genes is associated with gout.0
364688342023Constitutively active GPR43 is crucial for proper leukocyte differentiation.0
369655762023Dietary Fiber Improves Skin Wound Healing and Scar Formation through the Metabolite-Sensing Receptor GPR43.0
371858892023Butyrate dictates ferroptosis sensitivity through FFAR2-mTOR signaling.9
380856672023Phosphorylation bar-coding of free fatty acid receptor 2 is generated in a tissue-specific manner.1
357311422023Upregulated expression of FFAR2 and SOC3 genes is associated with gout.0
364688342023Constitutively active GPR43 is crucial for proper leukocyte differentiation.0
369655762023Dietary Fiber Improves Skin Wound Healing and Scar Formation through the Metabolite-Sensing Receptor GPR43.0
371858892023Butyrate dictates ferroptosis sensitivity through FFAR2-mTOR signaling.9

Citation

Dessen P

FFAR2 (free fatty acid receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-02-01

Online version: http://atlasgeneticsoncology.org/gene/52091/ffar2-(free-fatty-acid-receptor-2)