Identity
HGNC
LOCATION
11q12.2
LOCUSID
ALIAS
C11orf79,PGL2,SDH5
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 54949
MIM: 613019
HGNC: 26034
Ensembl: ENSG00000167985
Variants:
dbSNP: 54949
ClinVar: 54949
TCGA: ENSG00000167985
COSMIC: SDHAF2
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA35606 | SDHB | Gene | DataAnnotation | associated | |||
| PA35607 | SDHC | Gene | DataAnnotation | associated | |||
| PA35608 | SDHD | Gene | DataAnnotation | associated | |||
| PA445229 | Paraganglioma | Disease | DataAnnotation | associated | |||
| PA445315 | Pheochromocytoma | Disease | DataAnnotation | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32887801 | 2020 | The roles of SDHAF2 and dicarboxylate in covalent flavinylation of SDHA, the human complex II flavoprotein. | 16 |
| 32887801 | 2020 | The roles of SDHAF2 and dicarboxylate in covalent flavinylation of SDHA, the human complex II flavoprotein. | 16 |
| 31588224 | 2019 | SDH5 Depletion Enhances Radiosensitivity by Regulating p53: A New Method for Noninvasive Prediction of Radiotherapy Response. | 9 |
| 31588224 | 2019 | SDH5 Depletion Enhances Radiosensitivity by Regulating p53: A New Method for Noninvasive Prediction of Radiotherapy Response. | 9 |
| 28099933 | 2017 | Loss of maternal chromosome 11 is a signature event in SDHAF2, SDHD, and VHL-related paragangliomas, but less significant in SDHB-related paragangliomas. | 9 |
| 28384794 | 2017 | Clinical Characterization of the Pheochromocytoma and Paraganglioma Susceptibility Genes SDHA, TMEM127, MAX, and SDHAF2 for Gene-Informed Prevention. | 79 |
| 28099933 | 2017 | Loss of maternal chromosome 11 is a signature event in SDHAF2, SDHD, and VHL-related paragangliomas, but less significant in SDHB-related paragangliomas. | 9 |
| 28384794 | 2017 | Clinical Characterization of the Pheochromocytoma and Paraganglioma Susceptibility Genes SDHA, TMEM127, MAX, and SDHAF2 for Gene-Informed Prevention. | 79 |
| 27296776 | 2016 | In-vitro, SDH5-dependent flavinylation of immobilized human respiratory complex II flavoprotein. | 7 |
| 27587393 | 2016 | The Assembly Factor SDHAF2 Is Dispensable for Flavination of the Catalytic Subunit of Mitochondrial Complex II in Breast Cancer Cells. | 12 |
| 27296776 | 2016 | In-vitro, SDH5-dependent flavinylation of immobilized human respiratory complex II flavoprotein. | 7 |
| 27587393 | 2016 | The Assembly Factor SDHAF2 Is Dispensable for Flavination of the Catalytic Subunit of Mitochondrial Complex II in Breast Cancer Cells. | 12 |
| 24973967 | 2015 | A two-decade experience of head and neck paragangliomas in a whole population-based single centre cohort. | 3 |
| 24973967 | 2015 | A two-decade experience of head and neck paragangliomas in a whole population-based single centre cohort. | 3 |
| 24322175 | 2014 | Role of SDHAF2 and SDHD in von Hippel-Lindau associated pheochromocytomas. | 4 |
Citation
Dessen P
SDHAF2 (succinate dehydrogenase complex assembly factor 2)
Atlas Genet Cytogenet Oncol Haematol. 2011-03-01
Online version: http://atlasgeneticsoncology.org/gene/52113/sdhaf2-(succinate-dehydrogenase-complex-assembly-factor-2)
