Identity
HGNC
LOCATION
3q29
LOCUSID
ALIAS
CCTA,CCTalpha,CT,CTA,CTPCT,PCYT1,SMDCRD
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5130
MIM: 123695
HGNC: 8754
Ensembl: ENSG00000161217
Variants:
dbSNP: 5130
ClinVar: 5130
TCGA: ENSG00000161217
COSMIC: PCYT1A
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA450163 | lamivudine | Chemical | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33521992 | 2021 | Methylome and transcriptome profiling revealed epigenetic silencing of LPCAT1 and PCYT1A associated with lipidome alterations in polycystic ovary syndrome. | 5 |
| 33521992 | 2021 | Methylome and transcriptome profiling revealed epigenetic silencing of LPCAT1 and PCYT1A associated with lipidome alterations in polycystic ovary syndrome. | 5 |
| 31517566 | 2020 | De novo phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy. | 47 |
| 32186954 | 2020 | Differential dephosphorylation of CTP:phosphocholine cytidylyltransferase upon translocation to nuclear membranes and lipid droplets. | 7 |
| 32703435 | 2020 | PCYT1A suppresses proliferation and migration via inhibiting mTORC1 pathway in lung adenocarcinoma. | 3 |
| 31517566 | 2020 | De novo phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy. | 47 |
| 32186954 | 2020 | Differential dephosphorylation of CTP:phosphocholine cytidylyltransferase upon translocation to nuclear membranes and lipid droplets. | 7 |
| 32703435 | 2020 | PCYT1A suppresses proliferation and migration via inhibiting mTORC1 pathway in lung adenocarcinoma. | 3 |
| 30559292 | 2019 | Disease-linked mutations in the phosphatidylcholine regulatory enzyme CCTα impair enzymatic activity and fold stability. | 6 |
| 31488547 | 2019 | Interdomain communication in the phosphatidylcholine regulatory enzyme, CCTα, relies on a modular αE helix. | 3 |
| 31488548 | 2019 | Remodeling of the interdomain allosteric linker upon membrane binding of CCTα pulls its active site close to the membrane surface. | 4 |
| 30559292 | 2019 | Disease-linked mutations in the phosphatidylcholine regulatory enzyme CCTα impair enzymatic activity and fold stability. | 6 |
| 31488547 | 2019 | Interdomain communication in the phosphatidylcholine regulatory enzyme, CCTα, relies on a modular αE helix. | 3 |
| 31488548 | 2019 | Remodeling of the interdomain allosteric linker upon membrane binding of CCTα pulls its active site close to the membrane surface. | 4 |
| 30055775 | 2018 | PEMT rs12325817 and PCYT1A rs7639752 polymorphisms are associated with betaine but not choline concentrations in pregnant women. | 2 |
Citation
Dessen P
PCYT1A (phosphate cytidylyltransferase 1A, choline)
Atlas Genet Cytogenet Oncol Haematol. 2011-03-01
Online version: http://atlasgeneticsoncology.org/gene/52117
