LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1)

2011-03-01  

Identity

HGNC
LOCATION
11q13.4
LOCUSID
ALIAS
C11orf59,PDRO,Ragulator1,p18,p27RF-Rho
FUSION GENES

Other Information

Locus ID:

NCBI: 55004
MIM: 613510
HGNC: 26068
Ensembl: ENSG00000149357

Variants:

dbSNP: 55004
ClinVar: 55004
TCGA: ENSG00000149357
COSMIC: LAMTOR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149357ENST00000278671Q6IAA8
ENSG00000149357ENST00000535107F5H479
ENSG00000149357ENST00000535872F5H267
ENSG00000149357ENST00000538404F5H3Y3
ENSG00000149357ENST00000544594H0YFI1
ENSG00000149357ENST00000545249F5GX19

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
mTOR signaling pathwayKEGGhsa04150
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Signal TransductionREACTOMER-HSA-162582
Signaling by Insulin receptorREACTOMER-HSA-74752
Insulin receptor signalling cascadeREACTOMER-HSA-74751
IRS-mediated signallingREACTOMER-HSA-112399
PI3K CascadeREACTOMER-HSA-109704
PKB-mediated eventsREACTOMER-HSA-109703
mTOR signallingREACTOMER-HSA-165159
mTORC1-mediated signallingREACTOMER-HSA-166208
Energy dependent regulation of mTOR by LKB1-AMPKREACTOMER-HSA-380972
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)REACTOMER-HSA-2404192
IGF1R signaling cascadeREACTOMER-HSA-2428924
IRS-related events triggered by IGF1RREACTOMER-HSA-2428928
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203811372010Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.860
191771502009The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes.114
196543162009A novel protein associated with membrane-type 1 matrix metalloproteinase binds p27(kip1) and regulates RhoA activation, actin remodeling, and matrigel invasion.28
289357702017Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.27
289934672017LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning.19
276643302017Exosomal proteins as prostate cancer biomarkers in urine: From mass spectrometry discovery to immunoassay-based validation.18
210879312011A p27(kip1)-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA and RhoC.14
225138742012LAMTOR1 depletion induces p53-dependent apoptosis via aberrant lysosomal activation.8
260321662015Depletion of p18/LAMTOR1 promotes cell survival via activation of p27(kip1) -dependent autophagy under starvation.3
295478882018The TMEM127 human tumor suppressor is a component of the mTORC1 lysosomal nutrient-sensing complex.3

Citation

Dessen P

LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-03-01

Online version: http://atlasgeneticsoncology.org/gene/52126/lamtor1-(late-endosomal-lysosomal-adaptor-mapk-and-mtor-activator-1)