Identity
HGNC
LOCATION
5q13.2
LOCUSID
ALIAS
RGNEF,RIP2,p190RHOGEF
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 64283
MIM: 612790
HGNC: 30322
Ensembl: ENSG00000214944
Variants:
dbSNP: 64283
ClinVar: 64283
TCGA: ENSG00000214944
COSMIC: ARHGEF28
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Developmental Biology | REACTOME | R-HSA-1266738 |
| Axon guidance | REACTOME | R-HSA-422475 |
| EPH-Ephrin signaling | REACTOME | R-HSA-2682334 |
| EPHB-mediated forward signaling | REACTOME | R-HSA-3928662 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA447197 | Attention Deficit Disorder with Hyperactivity | Disease | ClinicalAnnotation | associated | PD | 29382897 | |
| PA450464 | methylphenidate | Chemical | ClinicalAnnotation | associated | PD | 29382897 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35422804 | 2022 | Expression of a RhoA-Specific Guanine Nucleotide Exchange Factor, p190RhoGEF, in Mouse Macrophages Negatively Affects M1 Polarization and Inflammatory Responses. | 4 |
| 35422804 | 2022 | Expression of a RhoA-Specific Guanine Nucleotide Exchange Factor, p190RhoGEF, in Mouse Macrophages Negatively Affects M1 Polarization and Inflammatory Responses. | 4 |
| 31060816 | 2020 | Rare, low-frequency and common coding variants of ARHGEF28 gene and their association with sporadic amyotrophic lateral sclerosis. | 4 |
| 32305958 | 2020 | Circular RNA circRGNEF promotes bladder cancer progression via miR-548/KIF2C axis regulation. | 18 |
| 32764283 | 2020 | Inclusion Formation and Toxicity of the ALS Protein RGNEF and Its Association with the Microtubule Network. | 4 |
| 31060816 | 2020 | Rare, low-frequency and common coding variants of ARHGEF28 gene and their association with sporadic amyotrophic lateral sclerosis. | 4 |
| 32305958 | 2020 | Circular RNA circRGNEF promotes bladder cancer progression via miR-548/KIF2C axis regulation. | 18 |
| 32764283 | 2020 | Inclusion Formation and Toxicity of the ALS Protein RGNEF and Its Association with the Microtubule Network. | 4 |
| 30482479 | 2019 | A novel overlapping NLS/NES region within the PH domain of Rho Guanine Nucleotide Exchange Factor (RGNEF) regulates its nuclear-cytoplasmic localization. | 5 |
| 31308489 | 2019 | Rgnef promotes ovarian tumor progression and confers protection from oxidative stress. | 18 |
| 30482479 | 2019 | A novel overlapping NLS/NES region within the PH domain of Rho Guanine Nucleotide Exchange Factor (RGNEF) regulates its nuclear-cytoplasmic localization. | 5 |
| 31308489 | 2019 | Rgnef promotes ovarian tumor progression and confers protection from oxidative stress. | 18 |
| 29196061 | 2018 | Direct regulation of p190RhoGEF by activated Rho and Rac GTPases. | 6 |
| 29196061 | 2018 | Direct regulation of p190RhoGEF by activated Rho and Rac GTPases. | 6 |
| 25922072 | 2015 | Gastrin-stimulated Gα13 Activation of Rgnef Protein (ArhGEF28) in DLD-1 Colon Carcinoma Cells. | 13 |
Citation
Dessen P
ARHGEF28 (Rho guanine nucleotide exchange factor 28)
Atlas Genet Cytogenet Oncol Haematol. 2011-03-01
Online version: http://atlasgeneticsoncology.org/gene/52147/arhgef28
