ARHGEF28 (Rho guanine nucleotide exchange factor 28)

2011-03-01  

Identity

HGNC
ARHGEF28
LOCATION
5q13.2
LOCUSID
64283
ALIAS
RGNEF,RIP2,p190RHOGEF
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64283
MIM: 612790
HGNC: 30322
Ensembl: ENSG00000214944

Variants:

dbSNP: 64283
ClinVar: 64283
TCGA: ENSG00000214944
COSMIC: ARHGEF28

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000214944ENST00000296794Q8N1W1
ENSG00000214944ENST00000296799Q8N1W1
ENSG00000214944ENST00000426542Q8N1W1
ENSG00000214944ENST00000437974Q8N1W1
ENSG00000214944ENST00000509848D6RAP0
ENSG00000214944ENST00000512883D6RGZ3
ENSG00000214944ENST00000513042Q8N1W1
ENSG00000214944ENST00000545377Q8N1W1

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHB-mediated forward signalingREACTOMER-HSA-3928662

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447197Attention Deficit Disorder with HyperactivityDiseaseClinicalAnnotationassociatedPD29382897
PA450464methylphenidateChemicalClinicalAnnotationassociatedPD29382897

References

Pubmed IDYearTitleCitations
354228042022Expression of a RhoA-Specific Guanine Nucleotide Exchange Factor, p190RhoGEF, in Mouse Macrophages Negatively Affects M1 Polarization and Inflammatory Responses.4
354228042022Expression of a RhoA-Specific Guanine Nucleotide Exchange Factor, p190RhoGEF, in Mouse Macrophages Negatively Affects M1 Polarization and Inflammatory Responses.4
310608162020Rare, low-frequency and common coding variants of ARHGEF28 gene and their association with sporadic amyotrophic lateral sclerosis.4
323059582020Circular RNA circRGNEF promotes bladder cancer progression via miR-548/KIF2C axis regulation.18
327642832020Inclusion Formation and Toxicity of the ALS Protein RGNEF and Its Association with the Microtubule Network.4
310608162020Rare, low-frequency and common coding variants of ARHGEF28 gene and their association with sporadic amyotrophic lateral sclerosis.4
323059582020Circular RNA circRGNEF promotes bladder cancer progression via miR-548/KIF2C axis regulation.18
327642832020Inclusion Formation and Toxicity of the ALS Protein RGNEF and Its Association with the Microtubule Network.4
304824792019A novel overlapping NLS/NES region within the PH domain of Rho Guanine Nucleotide Exchange Factor (RGNEF) regulates its nuclear-cytoplasmic localization.5
313084892019Rgnef promotes ovarian tumor progression and confers protection from oxidative stress.18
304824792019A novel overlapping NLS/NES region within the PH domain of Rho Guanine Nucleotide Exchange Factor (RGNEF) regulates its nuclear-cytoplasmic localization.5
313084892019Rgnef promotes ovarian tumor progression and confers protection from oxidative stress.18
291960612018Direct regulation of p190RhoGEF by activated Rho and Rac GTPases.6
291960612018Direct regulation of p190RhoGEF by activated Rho and Rac GTPases.6
259220722015Gastrin-stimulated Gα13 Activation of Rgnef Protein (ArhGEF28) in DLD-1 Colon Carcinoma Cells.13

Citation

Dessen P

ARHGEF28 (Rho guanine nucleotide exchange factor 28)

Atlas Genet Cytogenet Oncol Haematol. 2011-03-01

Online version: http://atlasgeneticsoncology.org/gene/52147/arhgef28-(rho-guanine-nucleotide-exchange-factor-28)