STING1 (stimulator of interferon response cGAMP interactor 1)

2011-03-01  

Identity

HGNC
STING1
LOCATION
5q31.2
LOCUSID
340061
ALIAS
ERIS,MITA,MPYS,NET23,SAVI,STING,STING-beta,TMEM173,hMITA,hSTING

Other Information

Locus ID:

NCBI: 340061
MIM: 612374
HGNC: 27962
Ensembl: ENSG00000184584

Variants:

dbSNP: 340061
ClinVar: 340061
TCGA: ENSG00000184584
COSMIC: STING1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184584ENST00000330794Q86WV6
ENSG00000184584ENST00000510817J3QTB1
ENSG00000184584ENST00000650883A0A494C1N5
ENSG00000184584ENST00000651565A0A494C0W5
ENSG00000184584ENST00000651699Q86WV6
ENSG00000184584ENST00000652110J3QTB1
ENSG00000184584ENST00000652271Q86WV6
ENSG00000184584ENST00000652543A0A494C0T1

Pathways

PathwaySourceExternal ID
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Cytosolic DNA-sensing pathwayKEGGko04623
Cytosolic DNA-sensing pathwayKEGGhsa04623
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cytosolic sensors of pathogen-associated DNAREACTOMER-HSA-1834949
STING mediated induction of host immune responsesREACTOMER-HSA-1834941
IRF3-mediated induction of type I IFNREACTOMER-HSA-3270619
STAT6-mediated induction of chemokinesREACTOMER-HSA-3249367
Regulation of innate immune responses to cytosolic DNAREACTOMER-HSA-3134975
Neutrophil degranulationREACTOMER-HSA-6798695

References

Pubmed IDYearTitleCitations
379317702024cGAS-STING at the crossroads in cancer therapy.1
379489792024Role of cGAS-STING in colorectal cancer: A new window for treatment strategies.0
379569182024Cardiovascular diseases crossroads: cGAS-STING signaling and disease progression.2
380075522024Activating STING/TBK1 suppresses tumor growth via degrading HPV16/18 E7 oncoproteins in cervical cancer.3
380383902024Cutting Edge: STING Induces ACLY Activation and Metabolic Adaptations in Human Macrophages through TBK1.2
380563692024Potential cGAS-STING pathway functions in DNA damage responses, DNA replication and DNA repair.0
380864882024The critical roles of STING in mitochondrial homeostasis.0
381860002024STING upregulation mediates ferroptosis and inflammatory response in lupus nephritis by upregulating TBK1 and activating NF-κB signal pathway.0
382160062024IUPHAR ECR review: The cGAS-STING pathway: Novel functions beyond innate immune and emerging therapeutic opportunities.0
382407032024Molecular map of cGAS-STING pathway-related genes in bladder cancer: the perspective toward immune microenvironment and prognosis.0
382718342024NRF2 mutation enhances the immune escape of hepatocellular carcinoma by reducing STING activation.0
382778172024FBXO38 deficiency promotes lysosome-dependent STING degradation and inhibits cGAS-STING pathway activation.1
383424182024Deubiquitinase OTUD6a drives cardiac inflammation and hypertrophy by deubiquitination of STING.0
383891032024Hypoxic glioblastoma-cell-derived extracellular vesicles impair cGAS-STING activity in macrophages.2
384014182024STING signalling compensates for low tumour mutation burden to drive anti-tumour immunity.0

Citation

Dessen P

STING1 (stimulator of interferon response cGAMP interactor 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-03-01

Online version: http://atlasgeneticsoncology.org/gene/52153