GYPA (glycophorin A (MNS blood group))

2011-04-01  

Identity

HGNC
GYPA
LOCATION
4q31.21
LOCUSID
2993
ALIAS
CD235a,GPA,GPErik,GPSAT,HGpMiV,HGpMiXI,HGpSta(C),MN,MNS,PAS-2

Other Information

Locus ID:

NCBI: 2993
MIM: 617922
HGNC: 4702
Ensembl: ENSG00000170180

Variants:

dbSNP: 2993
ClinVar: 2993
TCGA: ENSG00000170180
COSMIC: GYPA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170180ENST00000324022P02724
ENSG00000170180ENST00000360771A0A0C4DFT7
ENSG00000170180ENST00000503627E9PH25
ENSG00000170180ENST00000504786E7EQF3
ENSG00000170180ENST00000508337D6RJD8
ENSG00000170180ENST00000512064E9PD10
ENSG00000170180ENST00000512789Q13030
ENSG00000170180ENST00000535709A0A087WU29
ENSG00000170180ENST00000616983A0A087WU29
ENSG00000170180ENST00000641688A0A0C4DFT7
ENSG00000170180ENST00000642295A0A2R8Y7F9
ENSG00000170180ENST00000642713P02724
ENSG00000170180ENST00000642738K9JI14
ENSG00000170180ENST00000643148K9JIK7
ENSG00000170180ENST00000646447P02724

Expression (GTEx)

0
1
2
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Hematopoietic cell lineageKEGGko04640
Hematopoietic cell lineageKEGGhsa04640
MalariaKEGGko05144
MalariaKEGGhsa05144
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382310872024Aberrant GPA expression and regulatory function of red blood cells in sickle cell disease.0
382310872024Aberrant GPA expression and regulatory function of red blood cells in sickle cell disease.0
351386392022Characterization of alternatively spliced transcript variants of glycophorin A and glycophorin B genes in Chinese blood donors.0
361021662022Fatal haemolytic transfusion reaction due to anti-En(a) and identification of a novel GYPA c.295delG variant in a Thai family.1
351386392022Characterization of alternatively spliced transcript variants of glycophorin A and glycophorin B genes in Chinese blood donors.0
361021662022Fatal haemolytic transfusion reaction due to anti-En(a) and identification of a novel GYPA c.295delG variant in a Thai family.1
341468302021Diagnostic value of glycophorin-A in comparison with P57 immunohistochemical staining method in differentiating complete and partial molar pregnancies.1
341468302021Diagnostic value of glycophorin-A in comparison with P57 immunohistochemical staining method in differentiating complete and partial molar pregnancies.1
322019612020Characterization of GYP*Mur and novel GYP*Bun-like hybrids in Thai blood donors reveals a qualitatively altered s antigen.5
323588672020A new antigen SUMI carried on glycophorin A encoded by the GYPA*M with c.91A>C (p.Thr31Pro) belongs to the MNS blood group system.2
323944662020Novel hybrid genes and a splice site mutation encoding the St(a) antigen among Japanese blood donors.0
326002462020Structural variation of the malaria-associated human glycophorin A-B-E region.4
322019612020Characterization of GYP*Mur and novel GYP*Bun-like hybrids in Thai blood donors reveals a qualitatively altered s antigen.5
323588672020A new antigen SUMI carried on glycophorin A encoded by the GYPA*M with c.91A>C (p.Thr31Pro) belongs to the MNS blood group system.2
323944662020Novel hybrid genes and a splice site mutation encoding the St(a) antigen among Japanese blood donors.0

Citation

Dessen P

GYPA (glycophorin A (MNS blood group))

Atlas Genet Cytogenet Oncol Haematol. 2011-04-01

Online version: http://atlasgeneticsoncology.org/gene/52159/gypa-(glycophorin-a-(mns-blood-group))