CLCN3 (chloride voltage-gated channel 3)

2011-04-01  

Identity

HGNC
CLCN3
LOCATION
4q33
LOCUSID
1182
ALIAS
CLC3,ClC-3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1182
MIM: 600580
HGNC: 2021
Ensembl: ENSG00000109572

Variants:

dbSNP: 1182
ClinVar: 1182
TCGA: ENSG00000109572
COSMIC: CLCN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109572ENST00000347613P51790
ENSG00000109572ENST00000360642P51790
ENSG00000109572ENST00000504131A0A0A0MTB7
ENSG00000109572ENST00000507875E9PE15
ENSG00000109572ENST00000511092D6RDZ6
ENSG00000109572ENST00000512813D6RIX3
ENSG00000109572ENST00000513761P51790
ENSG00000109572ENST00000515420H0Y8Z8
ENSG00000109572ENST00000613795A0A087WU31

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
173609692007Superoxide flux in endothelial cells via the chloride channel-3 mediates intracellular signaling.76
128432582003Expression of voltage-gated chloride channels in human glioma cells.58
165226342006Anion channels, including ClC-3, are required for normal neutrophil oxidative function, phagocytosis, and transendothelial migration.58
201390892010Molecular interaction and functional regulation of ClC-3 by Ca2+/calmodulin-dependent protein kinase II (CaMKII) in human malignant glioma.52
150731682004AP-3-dependent mechanisms control the targeting of a chloride channel (ClC-3) in neuronal and non-neuronal cells.41
179779432008Overexpression of CLC-3 in HEK293T cells yields novel currents that are pH dependent.41
124710242003The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins.39
233452192013Bradykinin-induced chemotaxis of human gliomas requires the activation of KCa3.1 and ClC-3.34
211159012010Invasion of human glioma cells is regulated by multiple chloride channels including ClC-3.29
155964382005Regulation of intracellular Cl- concentration through volume-regulated ClC-3 chloride channels in A10 vascular smooth muscle cells.21

Citation

Dessen P

CLCN3 (chloride voltage-gated channel 3)

Atlas Genet Cytogenet Oncol Haematol. 2011-04-01

Online version: http://atlasgeneticsoncology.org/gene/52160/clcn3-(chloride-voltage-gated-channel-3)