LBR (lamin B receptor)

Identity

HGNC

LBR

LOCATION

1q42.12

LOCUSID

3930

ALIAS

C14SR,DHCR14B,LMN2R,PHA,PHASK,TDRD18

FUSION GENES

Show Gene Fusions

Other Information

Locus ID:

NCBI: 3930
MIM: 600024
HGNC: 6518
Ensembl: ENSG00000143815

Variants:

dbSNP: 3930
ClinVar: 3930
TCGA: ENSG00000143815
COSMIC: LBR

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000143815	ENST00000272163	Q14739
ENSG00000143815	ENST00000338179	Q14739
ENSG00000143815	ENST00000421383	C9JES9
ENSG00000143815	ENST00000425080	C9JXK0
ENSG00000143815	ENST00000651341	A0A494C1L1

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Expression (GTEx)

0

10

20

30

40

50

60

70

80

90

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cholesterol biosynthesis	REACTOME	R-HSA-191273
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
31825172	2020	Lamin B receptor plays a key role in cellular senescence induced by inhibition of the proteasome.	2
31911440	2020	Twin enzymes, divergent control: The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally.	11
32126237	2020	The role of lamin B receptor in the regulation of senescence-associated secretory phenotype (SASP).	11
33958580	2021	Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor.	10
33958580	2021	Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor.	10
34181735	2021	Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis.	7
34181735	2021	Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis.	7
35883595	2022	Knockdown of Lamin B1 and the Corresponding Lamin B Receptor Leads to Changes in Heterochromatin State and Senescence Induction in Malignant Melanoma.	10
35883595	2022	Knockdown of Lamin B1 and the Corresponding Lamin B Receptor Leads to Changes in Heterochromatin State and Senescence Induction in Malignant Melanoma.	10
36124691	2023	Nuclear envelope protein lamin B receptor protects the genome from chromosomal instability and tumorigenesis.	5

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Citation

Dessen P

LBR (lamin B receptor)

Atlas Genet Cytogenet Oncol Haematol. 2011-04-01

Online version: http://atlasgeneticsoncology.org/gene/52162