Identity
HGNC
LOCATION
1q42.12
LOCUSID
ALIAS
C14SR,DHCR14B,LMN2R,PHA,PHASK,TDRD18
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3930
MIM: 600024
HGNC: 6518
Ensembl: ENSG00000143815
Variants:
dbSNP: 3930
ClinVar: 3930
TCGA: ENSG00000143815
COSMIC: LBR
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Metabolism | REACTOME | R-HSA-1430728 |
| Metabolism of lipids and lipoproteins | REACTOME | R-HSA-556833 |
| Cholesterol biosynthesis | REACTOME | R-HSA-191273 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36124691 | 2023 | Nuclear envelope protein lamin B receptor protects the genome from chromosomal instability and tumorigenesis. | 5 |
| 36400164 | 2023 | Natural history and genetic spectrum of the Turkish metaphyseal dysplasia cohort, including rare types caused by biallelic COL10A1, COL2A1, and LBR variants. | 1 |
| 36598800 | 2023 | Differentiation-dependent changes in lamin B1 dynamics and lamin B receptor localization. | 2 |
| 36124691 | 2023 | Nuclear envelope protein lamin B receptor protects the genome from chromosomal instability and tumorigenesis. | 5 |
| 36400164 | 2023 | Natural history and genetic spectrum of the Turkish metaphyseal dysplasia cohort, including rare types caused by biallelic COL10A1, COL2A1, and LBR variants. | 1 |
| 36598800 | 2023 | Differentiation-dependent changes in lamin B1 dynamics and lamin B receptor localization. | 2 |
| 35883595 | 2022 | Knockdown of Lamin B1 and the Corresponding Lamin B Receptor Leads to Changes in Heterochromatin State and Senescence Induction in Malignant Melanoma. | 10 |
| 35883595 | 2022 | Knockdown of Lamin B1 and the Corresponding Lamin B Receptor Leads to Changes in Heterochromatin State and Senescence Induction in Malignant Melanoma. | 10 |
| 33958580 | 2021 | Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor. | 10 |
| 34181735 | 2021 | Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis. | 7 |
| 33958580 | 2021 | Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor. | 10 |
| 34181735 | 2021 | Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis. | 7 |
| 31825172 | 2020 | Lamin B receptor plays a key role in cellular senescence induced by inhibition of the proteasome. | 2 |
| 31911440 | 2020 | Twin enzymes, divergent control: The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally. | 11 |
| 32126237 | 2020 | The role of lamin B receptor in the regulation of senescence-associated secretory phenotype (SASP). | 11 |
Citation
Dessen P
LBR (lamin B receptor)
Atlas Genet Cytogenet Oncol Haematol. 2011-04-01
Online version: http://atlasgeneticsoncology.org/gene/52162/lbr-(lamin-b-receptor)
