ARPP19 (cAMP regulated phosphoprotein 19)

2011-04-01  

Identity

HGNC
ARPP19
LOCATION
15q21.2
LOCUSID
10776
ALIAS
ARPP-16,ARPP-19,ARPP16,ENSAL
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10776
MIM: 605487
HGNC: 16967
Ensembl: ENSG00000128989

Variants:

dbSNP: 10776
ClinVar: 10776
TCGA: ENSG00000128989
COSMIC: ARPP19

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128989ENST00000249822P56211
ENSG00000128989ENST00000249822A0A024R5U3
ENSG00000128989ENST00000561650P56211
ENSG00000128989ENST00000561971H3BMD8
ENSG00000128989ENST00000563277P56211
ENSG00000128989ENST00000563566P56211
ENSG00000128989ENST00000564163H3BMD8
ENSG00000128989ENST00000566423P56211
ENSG00000128989ENST00000566423A0A024R5U3
ENSG00000128989ENST00000567669P56211
ENSG00000128989ENST00000567669A0A024R5U3
ENSG00000128989ENST00000567830H3BTD3
ENSG00000128989ENST00000568196P56211
ENSG00000128989ENST00000569281P56211
ENSG00000128989ENST00000569281A0A024R5U3
ENSG00000128989ENST00000569723H3BQ52

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
MASTL Facilitates Mitotic ProgressionREACTOMER-HSA-2465910

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
257365972015MicroRNA-320a sensitizes tamoxifen-resistant breast cancer cells to tamoxifen by targeting ARPP-19 and ERRγ.24
117717492001Decreased levels of ARPP-19 and PKA in brains of Down syndrome and Alzheimer's disease.21
273802442016ARPP-19 promotes proliferation and metastasis of human glioma.9
215095942011Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma.6
286131562017Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition.6
255474872014Increased ARPP-19 expression is associated with hepatocellular carcinoma.4
319433392020LncRNA IGFL2-AS1 functions as a ceRNA in regulating ARPP19 through competitive binding to miR-802 in gastric cancer.1

Citation

Dessen P

ARPP19 (cAMP regulated phosphoprotein 19)

Atlas Genet Cytogenet Oncol Haematol. 2011-04-01

Online version: http://atlasgeneticsoncology.org/gene/52166/arpp19-(camp-regulated-phosphoprotein-19)