GPR18 (G protein-coupled receptor 18)

2011-04-01  

Identity

HGNC
GPR18
LOCATION
13q32.3
LOCUSID
2841
ALIAS
-

Other Information

Locus ID:

NCBI: 2841
MIM: 602042
HGNC: 4472
Ensembl: ENSG00000125245

Variants:

dbSNP: 2841
ClinVar: 2841
TCGA: ENSG00000125245
COSMIC: GPR18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125245ENST00000340807Q14330
ENSG00000125245ENST00000340807H9NIM1
ENSG00000125245ENST00000397470Q14330
ENSG00000125245ENST00000397470H9NIM1
ENSG00000125245ENST00000397473Q14330
ENSG00000125245ENST00000397473H9NIM1
ENSG00000125245ENST00000416594Q5JUH9

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
355253262022The resolvin D2 - GPR18 axis is expressed in human coronary atherosclerosis and transduces atheroprotection in apolipoprotein E deficient mice.0
355253262022The resolvin D2 - GPR18 axis is expressed in human coronary atherosclerosis and transduces atheroprotection in apolipoprotein E deficient mice.0
330583132021Novel selective agonist of GPR18, PSB-KK-1415 exerts potent anti-inflammatory and anti-nociceptive activities in animal models of intestinal inflammation and inflammatory pain.10
330583132021Novel selective agonist of GPR18, PSB-KK-1415 exerts potent anti-inflammatory and anti-nociceptive activities in animal models of intestinal inflammation and inflammatory pain.10
305037222019GPR18 expression on PMNs as biomarker for outcome in patient with sepsis.18
310759332019Towards A Molecular Understanding of The Cannabinoid Related Orphan Receptor GPR18: A Focus on Its Constitutive Activity.7
305037222019GPR18 expression on PMNs as biomarker for outcome in patient with sepsis.18
310759332019Towards A Molecular Understanding of The Cannabinoid Related Orphan Receptor GPR18: A Focus on Its Constitutive Activity.7
298707112018Molecular and functional interaction between GPR18 and cannabinoid CB(2) G-protein-coupled receptors. Relevance in neurodegenerative diseases.30
298707112018Molecular and functional interaction between GPR18 and cannabinoid CB(2) G-protein-coupled receptors. Relevance in neurodegenerative diseases.30
275729372016Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18.16
275729372016Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18.16
261957252015Identification of resolvin D2 receptor mediating resolution of infections and organ protection.204
261957252015Identification of resolvin D2 receptor mediating resolution of infections and organ protection.204
247620582014Activation of GPR18 by cannabinoid compounds: a tale of biased agonism.72

Citation

Dessen P

GPR18 (G protein-coupled receptor 18)

Atlas Genet Cytogenet Oncol Haematol. 2011-04-01

Online version: http://atlasgeneticsoncology.org/gene/52180/gpr18-(g-protein-coupled-receptor-18)