GP2 (glycoprotein 2)

2011-04-01

Identity

HGNC

GP2

LOCATION

16p12.3

LOCUSID

2813

ALIAS

ZAP75

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2813
MIM: 602977
HGNC: 4441
Ensembl: ENSG00000169347

Variants:

dbSNP: 2813
ClinVar: 2813
TCGA: ENSG00000169347
COSMIC: GP2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000169347	ENST00000302555	P55259
ENSG00000169347	ENST00000341642	P55259
ENSG00000169347	ENST00000381360	P55259
ENSG00000169347	ENST00000381362	P55259
ENSG00000169347	ENST00000572347	I3L4Y3
ENSG00000169347	ENST00000572478	I3L486
ENSG00000169347	ENST00000574982	I3L324
ENSG00000169347	ENST00000575449	I3L2Z7
ENSG00000169347	ENST00000575582	I3L3I2

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Expression (GTEx)

5000

10000

15000

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational modification: synthesis of GPI-anchored proteins	REACTOME	R-HSA-163125
Post-translational protein modification	REACTOME	R-HSA-597592

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Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
25968583	2015	Rediscovery of the Anti-Pancreatic Antibodies and Evaluation of their Prognostic Value in a Prospective Clinical Cohort of Crohn's Patients: The Importance of Specific Target Antigens [GP2 and CUZD1].	24
28835709	2017	Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors.	67
28835709	2017	Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors.	67
30233574	2018	Mucosal Autoimmunity to Cell-Bound GP2 Isoforms Is a Sensitive Marker in PSC and Associated With the Clinical Phenotype.	6
30233574	2018	Mucosal Autoimmunity to Cell-Bound GP2 Isoforms Is a Sensitive Marker in PSC and Associated With the Clinical Phenotype.	6
30411391	2018	Loss of tolerance to glycoprotein 2 isoforms 1 and 4 is associated with Crohn's disease of the pouch.	3
30411391	2018	Loss of tolerance to glycoprotein 2 isoforms 1 and 4 is associated with Crohn's disease of the pouch.	3
32581250	2020	Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer.	25
32581250	2020	Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer.	25
32886311	2021	Antibodies Against Glycoprotein 2 Are Specific Biomarkers for Pediatric Crohn's Disease.	2

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Citation

Dessen P

GP2 (glycoprotein 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-04-01

Online version: http://atlasgeneticsoncology.org/gene/52181