TPT1 (tumor protein, translationally-controlled 1)

2003-02-01  

Identity

HGNC
TPT1
LOCATION
13q14.13
LOCUSID
7178
ALIAS
HRF,TCTP,p02,p23
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7178
MIM: 600763
HGNC: 12022
Ensembl: ENSG00000133112

Variants:

dbSNP: 7178
ClinVar: 7178
TCGA: ENSG00000133112
COSMIC: TPT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133112ENST00000309246Q5W0H4
ENSG00000133112ENST00000379055P13693
ENSG00000133112ENST00000379055A0A024RDY2
ENSG00000133112ENST00000379056P13693
ENSG00000133112ENST00000379056A0A024RDY2
ENSG00000133112ENST00000379060J3KPG2
ENSG00000133112ENST00000527226E9PJF7
ENSG00000133112ENST00000528619H0YCX0
ENSG00000133112ENST00000530245H0YCX0
ENSG00000133112ENST00000530705P13693
ENSG00000133112ENST00000530705A0A0P1J1R0
ENSG00000133112ENST00000616577A0A0B4J2C3

Expression (GTEx)

0
500
1000
1500
2000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
367149752023Polymorphisms in TPT1 Pathways in Pediatric Astrocytomas.0
367356302023METTL13 promotes nasopharyngeal carcinoma progression through regulating the ZEB1/TPT1 axis.0
375738722023Elevated translationally controlled tumour protein promotes oral cancer progression and poor outcome.1
367149752023Polymorphisms in TPT1 Pathways in Pediatric Astrocytomas.0
367356302023METTL13 promotes nasopharyngeal carcinoma progression through regulating the ZEB1/TPT1 axis.0
375738722023Elevated translationally controlled tumour protein promotes oral cancer progression and poor outcome.1
351975502022Fortilin interacts with TGF-β1 and prevents TGF-β receptor activation.1
351975502022Fortilin interacts with TGF-β1 and prevents TGF-β receptor activation.1
331220782021TCTP participates in hepatic metabolism by regulating gene expression involved in insulin resistance.2
339993602021Long non-coding RNA TPT1-AS1 sensitizes breast cancer cell to paclitaxel and inhibits cell proliferation by miR-3156-5p/caspase 2 axis.10
342391212021Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells.21
343800152021The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state.25
331220782021TCTP participates in hepatic metabolism by regulating gene expression involved in insulin resistance.2
339993602021Long non-coding RNA TPT1-AS1 sensitizes breast cancer cell to paclitaxel and inhibits cell proliferation by miR-3156-5p/caspase 2 axis.10
342391212021Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells.21

Citation

Dessen P

TPT1 (tumor protein, translationally-controlled 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/522/tpt1-(tumor-protein-translationally-controlled-1)