ADGRE2 (adhesion G protein-coupled receptor E2)

2011-05-01 Affiliation

Identity

HGNC

ADGRE2

LOCATION

19p13.12

LOCUSID

30817

ALIAS

CD312,CD97,EMR2,VBU

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 30817
MIM: 606100
HGNC: 3337
Ensembl: ENSG00000127507

Variants:

dbSNP: 30817
ClinVar: 30817
TCGA: ENSG00000127507
COSMIC: ADGRE2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000127507	ENST00000315576	Q9UHX3
ENSG00000127507	ENST00000392962	B4DWB8
ENSG00000127507	ENST00000392965	Q9UHX3
ENSG00000127507	ENST00000594076	Q9UHX3
ENSG00000127507	ENST00000594294	Q9UHX3
ENSG00000127507	ENST00000595208	M0QY55
ENSG00000127507	ENST00000595839	Q9UHX3
ENSG00000127507	ENST00000596991	Q9UHX3
ENSG00000127507	ENST00000601345	M0R0K5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class B/2 (Secretin family receptors)	REACTOME	R-HSA-373080

References

Pubmed ID	Year	Title	Citations
15150276	2004	Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motif.	57
12829604	2003	The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans.	52
17928360	2008	Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function.	27
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	27
22310662	2012	Activation of myeloid cell-specific adhesion class G protein-coupled receptor EMR2 via ligation-induced translocation and interaction of receptor subunits in lipid raft microdomains.	22
12860403	2003	Proteolytic cleavage of the EMR2 receptor requires both the extracellular stalk and the GPS motif.	18
26841242	2016	Vibratory Urticaria Associated with a Missense Variant in ADGRE2.	18
29072692	2017	miR-99a reveals two novel oncogenic proteins E2F2 and EMR2 and represses stemness in lung cancer.	18
21174063	2011	Leukocyte adhesion-GPCR EMR2 is aberrantly expressed in human breast carcinomas and is associated with patient survival.	17
17174274	2007	CD312, the human adhesion-GPCR EMR2, is differentially expressed during differentiation, maturation, and activation of myeloid cells.	10

Citation

Dessen P

ADGRE2 (adhesion G protein-coupled receptor E2)

Atlas Genet Cytogenet Oncol Haematol. 2011-05-01

Online version: http://atlasgeneticsoncology.org/gene/52210/adgre2-(adhesion-g-protein-coupled-receptor-e2)