ULBP3 (UL16 binding protein 3)

2011-05-01  

Identity

HGNC
LOCATION
6q25.1
LOCUSID
ALIAS
N2DL-3,NKG2DL3,RAET1N

Other Information

Locus ID:

NCBI: 79465
MIM: 605699
HGNC: 14895
Ensembl: ENSG00000131019

Variants:

dbSNP: 79465
ClinVar: 79465
TCGA: ENSG00000131019
COSMIC: ULBP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131019ENST00000367339Q9BZM4
ENSG00000131019ENST00000438272Q9BZM4

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9

Pathways

PathwaySourceExternal ID
Natural killer cell mediated cytotoxicityKEGGko04650
Natural killer cell mediated cytotoxicityKEGGhsa04650
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
205960222010Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.146
197984332009HIV-1 Vpr triggers natural killer cell-mediated lysis of infected cells through activation of the ATR-mediated DNA damage response.72
213206922011An identical miRNA of the human JC and BK polyoma viruses targets the stress-induced ligand ULBP3 to escape immune elimination.65
117779602002UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells.52
150517592004Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D.38
205302552010Intracellular sequestration of the NKG2D ligand ULBP3 by human cytomegalovirus.29
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
246775442014c-Myc regulates expression of NKG2D ligands ULBP1/2/3 in AML and modulates their susceptibility to NK-mediated lysis.16
259952512015Varicella-Zoster Virus and Herpes Simplex Virus 1 Differentially Modulate NKG2D Ligand Expression during Productive Infection.16
196882092009Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais.8

Citation

Dessen P

ULBP3 (UL16 binding protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2011-05-01

Online version: http://atlasgeneticsoncology.org/gene/52222/ulbp3-(ul16-binding-protein-3)