URI1 (URI1 prefoldin like chaperone)

2011-06-01  

Identity

HGNC
LOCATION
19q12
LOCUSID
ALIAS
C19orf2,NNX3,PPP1R19,RMP,URI
FUSION GENES

Other Information

Locus ID:

NCBI: 8725
MIM: 603494
HGNC: 13236
Ensembl: ENSG00000105176

Variants:

dbSNP: 8725
ClinVar: 8725
TCGA: ENSG00000105176
COSMIC: URI1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105176ENST00000360605O94763
ENSG00000105176ENST00000392271O94763
ENSG00000105176ENST00000570564I3L2V7
ENSG00000105176ENST00000573052I3L0K5
ENSG00000105176ENST00000574110I3L467
ENSG00000105176ENST00000574233I3L104
ENSG00000105176ENST00000574666I3L130
ENSG00000105176ENST00000575242I3L280
ENSG00000105176ENST00000576442I3NI51
ENSG00000105176ENST00000585655K7EQZ9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
146155392003Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI.74
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
179367022007S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling.42
194506872009High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes.42
254539012014Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage.42
213978562011URI is an oncogene amplified in ovarian cancer cells and is required for their survival.27
217302892011Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP.23
275056732016Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms.22
246259852014URI regulates tumorigenicity and chemotherapeutic resistance of multiple myeloma by modulating IL-6 transcription.14
255271752015Characterization of the 19q12 amplification including CCNE1 and URI in different epithelial ovarian cancer subtypes.8

Citation

Dessen P

URI1 (URI1 prefoldin like chaperone)

Atlas Genet Cytogenet Oncol Haematol. 2011-06-01

Online version: http://atlasgeneticsoncology.org/gene/52232/uri1-(uri1-prefoldin-like-chaperone)